(Q33956803)

30 July 2017

title

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity (English)

1 reference

30 July 2017

5

Martin Egli

0 references

Michael McGuire

Michael H McGuire

6

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Hyun Jin Choi

Hyun J Choi

15

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Kshipra Gharpure

Kshipra M Gharpure

3

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Archana S. Nagaraja

Archana S Nagaraja

7

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Rajesha Rupaimoole

Rajesha Rupaimoole

9

0 references

Hiroto Hatakeyama

Hiroto Hatakeyama

Cristian Rodriguez-Aguayo

4

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Cristian Rodriguez-Aguayo

14

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Prahlad T. Ram

Prahlad T Ram

36

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Guillermo Armaiz-Pena

Guillermo N Armaiz-Pena

17

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Cristina Ivan

Cristina Ivan

21

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Khandan Keyomarsi

Khandan Keyomarsi

29

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Anil K. Sood

38

Anil K Sood

1 reference

30 July 2017

Gabriel Lopez-Berestein

35

Gabriel Lopez-Berestein

1 reference

30 July 2017

24

Hee-Dong Han

1 reference

30 July 2017

12

Sunila Pradeep

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30 July 2017

16

Rebecca A Previs

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30 July 2017

10

Chad V Pecot

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30 July 2017

22

Vasudha Sehgal

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30 July 2017

33

Ju-Seog Lee

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30 July 2017

2

Xianbin Yang

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30 July 2017

31

Willem W Overwijk

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30 July 2017

37

Barbara Nawrot

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30 July 2017

13

Malgorzata Sierant

1 reference

30 July 2017

Sherry Y Wu

1

1 reference

30 July 2017

Takahito M Miyake

8

1 reference

30 July 2017

Morgan Taylor

11

1 reference

30 July 2017

Li Huang

18

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30 July 2017

Carlos Martinez

19

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30 July 2017

Tom Hassell

20

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30 July 2017

Richa Singhania

23

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30 July 2017

Chang Su

25

1 reference

30 July 2017

Ji Hoon Kim

26

1 reference

30 July 2017

Heather J Dalton

27

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30 July 2017

Chandra Kovvali

28

1 reference

30 July 2017

Nigel A J McMillan

30

1 reference

30 July 2017

Jinsong Liu

32

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30 July 2017

Keith A Baggerly

34

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30 July 2017

language of work or name

English

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publication date

12 March 2014

1 reference

30 July 2017

published in

Nature Communications

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30 July 2017

volume

5

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30 July 2017

page(s)

3459

1 reference

describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4112501/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4112501

inferred from PubMed Central ID database lookup

cites work

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Src activation by β-adrenoreceptors is a key switch for tumour metastasis.

28 July 2018

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First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement

28 July 2018

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siRNA-optimized Modifications for Enhanced In Vivo Activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Asymmetric siRNA targeting the bcl‑2 gene inhibits the proliferation of cancer cells in vitro and in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Silencing survivin splice variant 2B leads to antitumor activity in taxane--resistant ovarian cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Pharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Making sense of cancer genomic data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

RNA interference in the clinic: challenges and future directions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Quantitative evaluation of siRNA delivery in vivo.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Lipidic systems for in vivo siRNA delivery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Selective protection of nuclease-sensitive sites in siRNA prolongs silencing effect

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Illuminating the silence: understanding the structure and function of small RNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Progress towards in vivo use of siRNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

UCSF Chimera--a visualization system for exploratory research and analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

siRNA function in RNAi: a chemical modification analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Molecular description of evolving paclitaxel resistance in the SKOV-3 human ovarian carcinoma cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Phosphorodithioate DNA as a potential therapeutic drug

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112501

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Chemical modification of siRNAs to improve serum stability without loss of efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Stem-loop RT-PCR quantification of siRNAs in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Dicer, Drosha, and outcomes in patients with ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4459

Comparison of standard and CA-125 response criteria in patients with epithelial ovarian cancer treated with platinum or paclitaxel

21 January 2018

1 reference

12 December 2020

Exploiting the potential of antisense: beyond phosphorothioate oligodeoxynucleotides

1 reference

12 December 2020

Separation of synthetic oligonucleotide dithioates from monothiophosphate impurities by anion-exchange chromatography on a mono-q column

1 reference

12 December 2020

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity

1 reference

12 December 2020

Synthesis of Phosphorodithioate DNA via Sulfur-Linked, Base-Labile Protecting Groups(1)

1 reference

12 December 2020

A specificity comparison of four antisense types: morpholino, 2'-O-methyl RNA, DNA, and phosphorothioate DNA

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS4459

1 reference

Dimensions Publication ID

30 July 2017

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1 reference

30 July 2017

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