(Q33959529)

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The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

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Europe PubMed Central

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5 February 2020

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy (English)

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5 February 2020

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Florence Raynaud

3

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5 February 2020

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5 February 2020

Ana Ramírez De Molina

5

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5 February 2020

Juan Carlos Lacal

6

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5 February 2020

8

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5 February 2020

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Nada M S Al-Saffar

1

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5 February 2020

L Elizabeth Jackson

2

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5 February 2020

Paul Workman

7

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5 February 2020

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15 June 2010

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5 February 2020

Cancer Research

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5 February 2020

70

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5 February 2020

13

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Europe PubMed Central

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5 February 2020

5507-5517

1 reference

Europe PubMed Central

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5 February 2020

describes a project that uses

NMR spectroscopy

1 reference

based on heuristic

inferred from title

Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

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Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine

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Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

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Molecular causes of the aberrant choline phospholipid metabolism in breast cancer

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Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K

1 reference

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-09-4476

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551061%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551061%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551061%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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