(Q46592766)

23 December 2017

title

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. (English)

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23 December 2017

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6

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23 December 2017

Almut Schulze

object named as

Almut Schulze

7

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author name string

Thomas Porstmann

1

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23 December 2017

Beatrice Griffiths

2

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23 December 2017

Yuen-Li Chung

3

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23 December 2017

Oona Delpuech

4

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23 December 2017

John R Griffiths

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23 December 2017

language of work or name

English

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publication date

1 September 2005

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23 December 2017

published in

Oncogene

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23 December 2017

volume

24

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23 December 2017

page(s)

6465-6481

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23 December 2017

issue

43

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23 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208802

exact match

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cites work

Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

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Fatty acid synthase: a metabolic oncogene in prostate cancer?

21 January 2018

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Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

21 January 2018

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Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

21 January 2018

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Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo

21 January 2018

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Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development

21 January 2018

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

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Transcriptional effects of chronic Akt activation in the heart.

21 January 2018

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Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers

21 January 2018

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Regulation of the rat SREBP-1c promoter in primary rat hepatocytes

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Cholesterol and prostate cancer

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AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

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Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c

21 January 2018

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

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Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c

21 January 2018

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

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Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element

21 January 2018

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

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Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.

21 January 2018

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MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

21 January 2018

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Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.

21 January 2018

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

21 January 2018

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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

21 January 2018

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Lipid rafts and signal transduction

21 January 2018

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Androgens, lipogenesis and prostate cancer.

21 January 2018

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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

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Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

21 January 2018

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

SREBP transcription factors: master regulators of lipid homeostasis

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

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7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208802

7 January 2021

Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208802

7 January 2021

Characterization of lipid composition in stimulated human lymphocytes by 1H-NMR

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7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208802

7 January 2021

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208802

7 January 2021

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208802

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208802

1 reference

23 December 2017

PubMed ID

16007182

1 reference

23 December 2017