(Q33961382)

30 July 2017

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title

Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans (English)

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30 July 2017

Fuhr U

1

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30 July 2017

1 June 2000

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Clinical Pharmacokinetics

30 July 2017

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30 July 2017

38

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30 July 2017

493-504

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30 July 2017

6

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Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization

30 July 2017

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12 December 2020

Clinically significant pharmacokinetic drug interactions with carbamazepine. An update

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12 December 2020

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma

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12 December 2020

Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis

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12 December 2020

Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase

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12 December 2020

Antiepileptic drugs. A review of clinically significant drug interactions.

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12 December 2020

Double-blind placebo-controlled study of the effects of bezafibrate on blood lipids, lipoproteins, and fibrinogen in hyperlipidaemic type 1 diabetes mellitus.

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12 December 2020

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design

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12 December 2020

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

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12 December 2020

A mechanistic approach to antiepileptic drug interactions

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12 December 2020

Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.

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12 December 2020

Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats.

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12 December 2020

Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type IIb hyperlipoproteinaemia

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12 December 2020

Clinical and toxicological consequences of the inductive potential of ethanol

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12 December 2020

Phenobarbital-mediated changes in gene expression in the liver

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12 December 2020

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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12 December 2020

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

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12 December 2020

Extent and character of phenobarbital-mediated changes in gene expression in the liver

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12 December 2020

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

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12 December 2020

Induction of liver microsomal cortisol 6beta-hydroxylase by diphenylhydantoin or phenobarbital: an explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugs

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12 December 2020

Monitoring of cytochrome P-450 1A activity by determination of the urinary pattern of caffeine metabolites in Wistar and hyperbilirubinemic Gunn rats

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12 December 2020

Pharmacokinetic interactions of antineoplastic agents

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12 December 2020

Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone

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12 December 2020

An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis

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12 December 2020

Mechanism of action of fibrates on lipid and lipoprotein metabolism

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12 December 2020

Absence of the glutathione S-transferase M1 gene increases cytochrome P4501A2 activity among frequent consumers of cruciferous vegetables in a Caucasian population.

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12 December 2020

Reaction of drugs with microsomal liver hydroxylase: its influence on drug action

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12 December 2020

Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children

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12 December 2020

Clinical implications of enzyme induction

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12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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12 December 2020

Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1

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12 December 2020

Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.

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12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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12 December 2020

Fractionated administration of high-dose cyclophosphamide: influence on dose-dependent changes in pharmacokinetics and metabolism

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12 December 2020

Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance

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12 December 2020

Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data

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12 December 2020

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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12 December 2020

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

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12 December 2020

Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers

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12 December 2020

Cigarette smoking and clinically significant drug interactions

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12 December 2020

Effects of chronic phenobarbital on verapamil disposition in humans

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12 December 2020

Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation.

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12 December 2020

CYP1A2 activity as a risk factor for bladder cancer

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12 December 2020

Pharmacokinetic drug interactions with phenytoin (Part II).

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12 December 2020

Pharmacokinetic drug interactions with phenytoin (Part I).

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12 December 2020

AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms

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12 December 2020

Relationship between patient variables and plasma clozapine concentrations: a dosing nomogram.

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12 December 2020

Application of population pharmacokinetics to the optimization of theophylline therapy.

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12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

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12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

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12 December 2020

Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers

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12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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12 December 2020

Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.

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12 December 2020

Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression

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12 December 2020

The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs

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12 December 2020

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

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12 December 2020

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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12 December 2020

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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12 December 2020

Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine

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12 December 2020

Effects of inducer of liver drug-metabolizing enzyme on blood level of active metabolites of cyclophosphamide in rats and in cancer patients

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12 December 2020

Specific and dose-dependent enzyme induction by omeprazole in human beings.

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12 December 2020

Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients

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12 December 2020

10.1097/00004714-200008000-00019

Identifiers

DOI

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30 July 2017

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