(Q33968465)

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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Europe PubMed Central

30 July 2017

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression (English)

1 reference

Europe PubMed Central

30 July 2017

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Gregg L. Semenza

5

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G L Semenza

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Europe PubMed Central

30 July 2017

author name string

E Laughner

1

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Europe PubMed Central

30 July 2017

P Taghavi

2

1 reference

Europe PubMed Central

30 July 2017

K Chiles

3

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Europe PubMed Central

30 July 2017

P C Mahon

4

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30 July 2017

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publication date

1 June 2001

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30 July 2017

Molecular and Cellular Biology

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Europe PubMed Central

30 July 2017

21

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Europe PubMed Central

30 July 2017

3995-4004

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Europe PubMed Central

30 July 2017

12

1 reference

Europe PubMed Central

30 July 2017

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

1 reference

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Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

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Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

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Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis

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Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

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Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

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Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

1 reference

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Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

1 reference

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5 July 2018

Loss of PTEN facilitates HIF-1-mediated gene expression

1 reference

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

1 reference

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

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Ribosomal S6 kinase signaling and the control of translation

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5 July 2018

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors

1 reference

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5 July 2018

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1 reference

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5 July 2018

Heregulin regulation of Akt/protein kinase B in breast cancer cells

1 reference

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

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5 July 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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5 July 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

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HER-2/neu as a predictive marker of response to breast cancer therapy

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

5 July 2018

The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

5 July 2018

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

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Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

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1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

5 July 2018

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

5 July 2018

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

1 reference

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1 reference

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

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Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy

1 reference

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V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1 reference

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

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1 reference

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

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The biology of vascular endothelial growth factor

1 reference

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The role of angiogenic growth factors in breast cancer progression.

1 reference

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

5 July 2018

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

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Purification and characterization of hypoxia-inducible factor 1

1 reference

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1 reference

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1 reference

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1 reference

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Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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Oncogenic potential of erbB-2 in human mammary epithelial cells

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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87062

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Correlation of Vascular Endothelial Growth Factor Content With Recurrences, Survival, and First Relapse Site in Primary Node-Positive Breast Carcinoma After Adjuvant Treatment

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Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma

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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer

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Identifiers

10.1128/MCB.21.12.3995-4004.2001

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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