(Q33972094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

Ezequiel Marron Fernandez de Velasco

8 March 2020

author

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Mark J. Thomas

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Kevin Wickman

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Nicole Wydeven

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Yu Du

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Michael A Benneyworth

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Matthew C Hearing

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Rachel A Fischer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

C David Weaver

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

language of work or name

English

0 references

publication date

7 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

8 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

10755-10760

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels

8 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

X-ray structure of the mammalian GIRK2–βγ G-protein complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Altered neurotransmission in the mesolimbic reward system of Girk mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Inwardly rectifying potassium channels: their structure, function, and physiological roles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

A discrete alcohol pocket involved in GIRK channel activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Voltage-sensing phosphatase: actions and potentials

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

G protein-activated inwardly rectifying potassium channels as potential therapeutic targets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Ethanol opens G-protein-activated inwardly rectifying K+ channels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Molecular determinants for sodium-dependent activation of G protein-gated K+ channels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Stress-induced hyperthermia in singly housed mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115558

New insights into the therapeutic potential of Girk channels.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Identification of structural elements involved in G protein gating of the GIRK1 potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein‐gated inwardly rectifying potassium currents in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405190111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1405190111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

25002517

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json