(Q33993114)

30 July 2017

title

VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids (English)

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30 July 2017

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Maxwell A Ruby

1

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author name string

Benjamin Goldenson

2

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30 July 2017

Gabriela Orasanu

3

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30 July 2017

Thomas P Johnston

4

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30 July 2017

Jorge Plutzky

5

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30 July 2017

Ronald M Krauss

6

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30 July 2017

publication date

26 April 2010

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Journal of Lipid Research

30 July 2017

published in

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30 July 2017

volume

51

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30 July 2017

issue

8

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30 July 2017

page(s)

2275-2281

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Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators

30 July 2017

cites work

1 reference

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Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models

5 July 2018

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Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation

5 July 2018

1 reference

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The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

PPARdelta is a very low-density lipoprotein sensor in macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Unbound free fatty acid levels in human serum.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903797

Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.

5 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Lipoprotein lipase activator NO-1886 (ibrolipim) accelerates the mRNA expression of fatty acid oxidation-related enzymes in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Perfusion of hearts with triglyceride-rich particles reproduces the metabolic abnormalities in lipotoxic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Routes of FA delivery to cardiac muscle: modulation of lipoprotein lipolysis alters uptake of TG-derived FA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M005561

Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1

21 January 2018

1 reference

12 December 2020

VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial

1 reference

12 December 2020

Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants

1 reference

12 December 2020

Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin

1 reference

12 December 2020

Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes

1 reference

12 December 2020

Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M005561

1 reference

30 July 2017

1 reference

30 July 2017

1 reference