(Q33993570)

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Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections (English)

1 reference

Europe PubMed Central

30 July 2017

1 reference

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Megan J Smithey

object named as

Megan J Smithey

2

0 references

Jennifer L Uhrlaub

object named as

Jennifer L Uhrlaub

4

0 references

Janko Nikolich-Žugich

5

object named as

Janko Nikolich-Žugich

1 reference

Europe PubMed Central

30 July 2017

Emily L Goldberg

1

object named as

Emily L Goldberg

1 reference

Europe PubMed Central

30 July 2017

author name string

Lydia K Lutes

3

1 reference

Europe PubMed Central

30 July 2017

language of work or name

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publication date

9 June 2014

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Europe PubMed Central

30 July 2017

Journal of Immunology

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Europe PubMed Central

30 July 2017

193

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Europe PubMed Central

30 July 2017

2

1 reference

Europe PubMed Central

30 July 2017

757-763

1 reference

Europe PubMed Central

30 July 2017

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

1 reference

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The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.

1 reference

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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

1 reference

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Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

1 reference

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Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

1 reference

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Rapamycin extends murine lifespan but has limited effects on aging

1 reference

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Posttranscriptional control of T cell effector function by aerobic glycolysis

1 reference

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Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response

1 reference

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West Nile virus infection and immunity

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

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Rapamycin slows aging in mice

1 reference

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1 reference

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1 reference

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

1 reference

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1 reference

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Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

1 reference

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5 July 2018

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

1 reference

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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

1 reference

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Metabolism, migration and memory in cytotoxic T cells

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mTOR: from growth signal integration to cancer, diabetes and ageing

1 reference

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1 reference

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1 reference

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Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses

1 reference

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Key role of T cell defects in age-related vulnerability to West Nile virus

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

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mTOR regulates memory CD8 T-cell differentiation

1 reference

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

1 reference

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Monocyte-mediated defense against microbial pathogens.

1 reference

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

1 reference

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Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

1 reference

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Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection

1 reference

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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

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1 reference

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Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

1 reference

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The LCMV gp33-specific memory T cell repertoire narrows with age.

1 reference

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1 reference

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

1 reference

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Immunology: A metabolic switch to memory.

1 reference

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Cutting edge: rapid in vivo killing by memory CD8 T cells.

1 reference

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Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection

1 reference

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29 October 2018

Identifiers

10.4049/JIMMUNOL.1400188

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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