(Q33995061)

PubMed publication ID

30 July 2017

1 reference

title

A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

author name string

A C Berends

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

P G M Luiten

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

C Nyakas

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

publication date

1 January 2005

1 reference

PubMed publication ID

16614737

CNS Neuroscience & Therapeutics

30 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

page(s)

379-402

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades.

12 May 2020

cites work

1 reference

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Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke.

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Cerestat and other NMDA antagonists in ischemic stroke

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Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

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S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke.

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Type and extent of hemispheric brain infarctions and clinical outcome in early and delayed middle cerebral artery recanalization

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Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells

21 January 2018

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12 December 2020

Behavioural and morphological outcome of mild cortical contusion trauma of the rat brain: influence of NMDA-receptor blockade.

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12 December 2020

Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

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12 December 2020

The 5-HT1A receptor agonist Bay x 3702 inhibits apoptosis induced by serum deprivation in cultured neurons.

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12 December 2020

Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY x 3702 in freely moving rats.

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12 December 2020

Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex.

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Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes

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Overexpression of a calcium-binding protein, S100 beta, in astrocytes alters synaptic plasticity and impairs spatial learning in transgenic mice.

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The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat.

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Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

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12 December 2020

S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702

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12 December 2020

5-Hydroxytryptamine1A receptor/Gibetagamma stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of src in chinese hamster ovary fibroblasts

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12 December 2020

Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death

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12 December 2020

In vivo actions of the selective 5-HT1A receptor agonist BAY x 3702 on serotonergic cell firing and release

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12 December 2020

Blockade of voltage-sensitive Na(+) channels by the 5-HT(1A) receptor agonist 8-OH-DPAT: possible significance for neuroprotection

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12 December 2020

Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat

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12 December 2020

Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine

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12 December 2020

Evaluation of combined fibroblast growth factor-2 and moderate hypothermia therapy in traumatically brain injured rats.

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12 December 2020

LY393615, a novel neuronal Ca(2+) and Na(+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia.

1 reference

12 December 2020

Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo

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12 December 2020

S-100 serum levels and outcome after severe head injury.

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12 December 2020

The selective 5-HT(1A) receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats

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12 December 2020

Effect of 5-hydroxytryptamine 1A receptor agonist BAY X 3702 on BCL-2 and BAX proteins level in the ipsilateral cerebral cortex of rats after transient focal ischaemia.

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12 December 2020

Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular nucleus basalis: effects on in vivo labelling of cholinergic neurons

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12 December 2020

Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis

1 reference

12 December 2020

Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis.

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12 December 2020

Repinotan (BAY x 3702): a 5HT1A agonist in traumatically brain injured patients

1 reference

12 December 2020

Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury

1 reference

12 December 2020

The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha

1 reference

12 December 2020

Neuroprotective effect of NS-7, a novel Na+ and Ca2+ channel blocker, in a focal ischemic model in the rat.

1 reference

12 December 2020

Mechanisms, challenges and opportunities in stroke

1 reference

12 December 2020

Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes.

1 reference

12 December 2020

In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs.

1 reference

12 December 2020

Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists

1 reference

12 December 2020

Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment

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12 December 2020

Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures

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12 December 2020

Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels

1 reference

12 December 2020

The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization

1 reference

12 December 2020

Glutamate in CNS disorders as a target for drug development: an update

1 reference

12 December 2020

Neuroprotective efficacy of repinotan HCl, a 5-HT1A receptor agonist, in animal models of stroke and traumatic brain injury

1 reference

12 December 2020

Neurodegeneration: cellular defences destroyed

1 reference

12 December 2020

Pharmacokinetics of repinotan in healthy and brain injured animals

1 reference

12 December 2020

Head injury therapies.

1 reference

12 December 2020

Trends in the leading causes of death in the United States, 1970-2002.

1 reference

12 December 2020

Rescue from programmed cell death in leukemic and normal myeloid cells

1 reference

12 December 2020

Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices

1 reference

12 December 2020

Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons

1 reference

12 December 2020

Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system

1 reference

12 December 2020

Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain — a combined in situ hybridisation/in vitro receptor autoradiographic study

1 reference

12 December 2020

Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia

1 reference

12 December 2020

Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain

1 reference

12 December 2020

5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment

1 reference

12 December 2020

Effects of 5-hydroxytryptamine1A-receptor agonists on hippocampal damage after transient forebrain ischemia in the Mongolian gerbil.

1 reference

12 December 2020

Beta-adrenergic receptor regulation, through cyclic AMP, of nerve growth factor expression in rat cortical and cerebellar astrocytes

1 reference

12 December 2020

S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor.

1 reference

12 December 2020

Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology.

1 reference

12 December 2020

Protective effect of MK801 in experimental brain injury

1 reference

12 December 2020

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

1 reference

12 December 2020

Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein

1 reference

12 December 2020

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

1 reference

12 December 2020

Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system

1 reference

12 December 2020

Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype.

1 reference

12 December 2020

Anti-S-100 serum blocks long-term potentiation in the hippocampal slice.

1 reference

12 December 2020

Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT

1 reference

12 December 2020

Autoregulation of fetal serotonergic neuronal development: role of high affinity serotonin receptors.

1 reference

12 December 2020

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia

1 reference

12 December 2020

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion.

1 reference

12 December 2020

A soluble protein characteristic of the nervous system

1 reference

12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

12 December 2020

5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain

1 reference

12 December 2020

The S-100: a protein family in search of a function

1 reference

12 December 2020

S100 beta protects hippocampal neurons from damage induced by glucose deprivation

1 reference

12 December 2020

Rapid serotonergic fiber sprouting in response to ibotenic acid lesion in the striatum and hippocampus

1 reference

12 December 2020

Intracerebral inflammatory response to experimental brain contusion.

1 reference

12 December 2020

Nimodipine prevents early loss of hippocampal CA1 parvalbumin immunoreactivity after focal cerebral ischemia in the rat

1 reference

12 December 2020

Characterisation of the binding of [3H]WAY-100635, a novel 5-hydroxytryptamine1A receptor antagonist, to rat brain

1 reference

12 December 2020

Serotonergic inhibition of extracellular glutamate in the suprachiasmatic nuclear region assessed using in vivo brain microdialysis

1 reference

12 December 2020

Astroglial 5-HT1a receptors and S-100 beta in development and plasticity.

1 reference

12 December 2020

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

12 December 2020

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)

1 reference

12 December 2020

Blood-brain barrier disruption in experimental focal ischemia: comparison between in vivo MRI and immunocytochemistry.

1 reference

12 December 2020

Relationship between extracellular neurotransmitter amino acids and energy metabolism during cerebral ischemia in rats monitored by microdialysis and in vivo magnetic resonance spectroscopy.

1 reference

12 December 2020

Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). II. Co-cultures study.

1 reference

12 December 2020

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1 reference

12 December 2020

Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons.

1 reference

12 December 2020

Hippocampal serotonin levels influence the expression of S100 beta detected by immunocytochemistry

1 reference

12 December 2020

Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists

1 reference

12 December 2020

5-HT1A receptor agonists: recent developments and controversial issues

1 reference

12 December 2020

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

1 reference

12 December 2020

Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment.

1 reference

12 December 2020

Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats.

1 reference

12 December 2020

Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF

1 reference

12 December 2020

Changes in levels of monoamines and their metabolites in incompletely ischemic brains of spontaneously hypertensive rats

1 reference

12 December 2020

In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection

1 reference

12 December 2020

Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways.

1 reference

12 December 2020

Regulation of glutamate release via NMDA and 5-HT1A receptors in guinea pig dentate gyrus

1 reference

12 December 2020

Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats.

1 reference

12 December 2020

Nerve growth factor inhibits apoptosis induced by S-100 binding in neuronal PC12 cells.

1 reference

12 December 2020

Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy.

1 reference

12 December 2020

Treatment of traumatic brain injury with moderate hypothermia.

1 reference

12 December 2020

5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells.

1 reference

12 December 2020

6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.

1 reference

12 December 2020

Role of hippocampal serotonergic neurons in ischemic neuronal death

1 reference

12 December 2020

Clinical neuro-protection trials in severe traumatic brain injury: lessons from previous studies

1 reference

12 December 2020

Effects of the novel NMDA antagonists CP-98,113, CP-101,581 and CP-101,606 on cognitive function and regional cerebral edema following experimental brain injury in the rat.

1 reference

12 December 2020

A new role for an old molecule: serotonin as a mitogen

1 reference

12 December 2020

Two parallel signaling pathways couple 5HT1A receptors to N- and L-type calcium channels in C-like rat dorsal root ganglion cells

1 reference

12 December 2020

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

1 reference

12 December 2020

Effect of prior receptor antagonism on behavioral morbidity produced by combined fluid percussion injury and entorhinal cortical lesion

1 reference

12 December 2020

The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain

1 reference

12 December 2020

Stimulation of 5-HT1A receptor inhibits apoptosis induced by serum deprivation in cultured neurons from chick embryo.

1 reference

12 December 2020

Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat.

1 reference

12 December 2020

Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist

1 reference

12 December 2020

Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients.

1 reference

12 December 2020

Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists.

1 reference

12 December 2020

Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe.

1 reference

12 December 2020

Glutamate antagonism during secondary deafferentation enhances cognition and axo-dendritic integrity after traumatic brain injury

1 reference

12 December 2020

Apoptotic pathways: the roads to ruin

1 reference

12 December 2020

The 5-HT1A receptor agonist BAY x 3702 prevents staurosporine-induced apoptosis.

1 reference

12 December 2020

Discriminative stimulus properties of the 5-HT1A receptor agonist BAY x 3702 in the rat.

1 reference

12 December 2020

Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors.

1 reference

12 December 2020

Neuroprotective effect of 5-HT1A receptor agonist, Bay X 3702, demonstrated in vitro and in vivo.

1 reference

12 December 2020

Molecular and cellular mechanism of angiotensin II-mediated apoptosis

1 reference

12 December 2020

G-proteins are involved in 5-HT receptor-mediated modulation of N- and P/Q- but not T-type Ca2+ channels

1 reference

12 December 2020

Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis

1 reference

12 December 2020

10.1111/J.1527-3458.2005.TB00055.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json

12 May 2020

PubMed publication ID

16614737

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741728&resulttype=core&format=json