(Q34000779)

30 July 2017

title

Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells (English)

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30 July 2017

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8

Michael Aschner

1 reference

Marta Sidoryk-Wegrzynowicz

30 July 2017

5

object named as

Marta Sidoryk-Wegrzynowicz

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30 July 2017

6

Dejan Milatovic

1 reference

30 July 2017

Mingwei Ni

1

1 reference

30 July 2017

Xin Li

2

1 reference

30 July 2017

Zhaobao Yin

3

1 reference

30 July 2017

Haiyan Jiang

4

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30 July 2017

Jiyang Cai

7

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30 July 2017

publication date

26 April 2010

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30 July 2017

published in

Toxicological Sciences

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30 July 2017

volume

116

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30 July 2017

issue

2

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30 July 2017

page(s)

590-603

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Neonatal rat primary microglia: isolation, culturing, and selected applications

30 July 2017

cites work

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5 July 2018

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tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation

5 July 2018

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Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes

5 July 2018

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The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter

5 July 2018

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Molecular mechanisms of Nrf2-mediated antioxidant response

5 July 2018

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Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells

5 July 2018

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Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro

5 July 2018

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Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity

5 July 2018

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Microglial activation and its implications in the brain diseases.

5 July 2018

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Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent

5 July 2018

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Methylmercury causes glial IL-6 release

5 July 2018

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Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes.

5 July 2018

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Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury

5 July 2018

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Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

5 July 2018

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Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

5 July 2018

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Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells

5 July 2018

1 reference

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High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation

5 July 2018

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Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2.

5 July 2018

1 reference

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Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes

5 July 2018

1 reference

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

5 July 2018

1 reference

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

5 July 2018

1 reference

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Methylmercury neurotoxicity in cultures of human neurons, astrocytes, neuroblastoma cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Induction of apoptosis by mercury compounds depends on maturation and is not associated with microglial activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Oxidative stress in neurotoxic effects of methylmercury poisoning.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Chemical and molecular regulation of enzymes that detoxify carcinogens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Establishment and characterization of methylmercury-resistant PC12 cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Disruption of brain mitochondrial calcium sequestration by methylmercury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Alkylmercurial encephalopathy in the monkey (Saimiri sciureus and Macaca arctoides): a histopathologic and autoradiographic study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Persistent, bioaccumulative and toxic substances in fish: human health considerations.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Phagocytic clearance of apoptotic neurons by Microglia/Brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Reduced methylmercury accumulation in a methylmercury-resistant rat pheochromocytoma PC12 cell line

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

The role of -SH groups in methylmercuric chloride-induced D-aspartate and rubidium release from rat primary astrocyte cultures

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Effects of trimethyltin (TMT) on glial and neuronal cells in aggregate cultures: dependence on the developmental stage

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905400

Biological Methylation of Mercury in Aquatic Organisms

29 October 2018

1 reference

12 December 2020

Cellular mechanisms underlying the increase in cytosolic free calcium concentration induced by methylmercury in cerebrocortical synaptosomes from guinea pig

1 reference

12 December 2020

Brain macrophages: evaluation of microglia and their functions

1 reference

12 December 2020

Stimulation of D-aspartate efflux by mercuric chloride from rat primary astrocyte cultures

1 reference

12 December 2020

Autometallographic determination of inorganic mercury distribution in the cortex of the calcarine sulcus of the monkey Macaca fascicularis following long-term subclinical exposure to methylmercury and mercuric chloride

1 reference

12 December 2020

Trimethyltin increases interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha mRNA levels in rat hippocampus

1 reference

12 December 2020

Microglia: Intrinsic immuneffector cell of the brain

1 reference

12 December 2020

Interleukin-1β Enhances Survival and Interleukin-6 Protects against MPP+ Neurotoxicity in Cultures of Fetal Rat Dopaminergic Neurons

1 reference

12 December 2020

CONSIDERATION OF THE TOXICITY OF METHYLMERCURIC COMPOUNDS AND THE CAUSATIVE AGENT OF MINAMATA DISEASE

1 reference

12 December 2020

Methylmercury risk and awareness among American Indian women of childbearing age living on an inland northwest reservation

1 reference

12 December 2020

Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

1 reference

12 December 2020

Microglial reaction induced by noncytotoxic methylmercury treatment leads to neuroprotection via interactions with astrocytes and IL-6 release

1 reference

12 December 2020

Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release, microglial activation, and neurodegeneration induced by trimethyltin

1 reference

12 December 2020

Identifiers

DOI

10.1093/TOXSCI/KFQ126

1 reference

30 July 2017

1 reference

30 July 2017

1 reference