(Q34003813)

30 July 2017

1 reference

title

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery (English)

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30 July 2017

0 references

1 reference

1 reference

Liang Tong

4

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author name string

Javed A Khan

series ordinal

1

1 reference

30 July 2017

Farhad Forouhar

series ordinal

2

1 reference

30 July 2017

Xiao Tao

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 May 2007

1 reference

Expert Opinion on Therapeutic Targets

30 July 2017

published in

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30 July 2017

volume

11

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30 July 2017

issue

5

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30 July 2017

page(s)

695-705

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Enzymology of NAD+ homeostasis in man.

30 July 2017

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Introduction to poly(ADP-ribose) metabolism

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Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?

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The biochemistry of sirtuins.

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Calorie restriction--the SIR2 connection

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The Sir2 family of protein deacetylases

21 January 2018

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Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).

21 January 2018

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Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.

21 January 2018

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Reconstructing eukaryotic NAD metabolism

21 January 2018

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Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism

21 January 2018

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Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase

21 January 2018

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Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis

21 January 2018

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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

21 January 2018

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Three-dimensional structure of kynureninase from Pseudomonas fluorescens

21 January 2018

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Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis

21 January 2018

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Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

21 January 2018

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Structure and function of nicotinamide mononucleotide adenylyltransferase.

21 January 2018

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Quinolinate phosphoribosyltransferase: kinetic mechanism for a type II PRTase

21 January 2018

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase

21 January 2018

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Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin

21 January 2018

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Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis

21 January 2018

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Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD

21 January 2018

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Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

21 January 2018

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Crystal structure of NH3-dependent NAD+ synthetase from Helicobacter pylori.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Crystal structure of a nicotinate phosphoribosyltransferase from Thermoplasma acidophilum

21 January 2018

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The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases

21 January 2018

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Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

21 January 2018

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Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

21 January 2018

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

21 January 2018

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Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866

21 January 2018

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Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

21 January 2018

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Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor

21 January 2018

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RETRACTED: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

21 January 2018

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Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii

21 January 2018

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Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

21 January 2018

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Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis

21 January 2018

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Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities

21 January 2018

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Coupling of NAD+ biosynthesis and nicotinamide ribosyl transport: characterization of NadR ribonucleotide kinase mutants of Haemophilus influenzae

21 January 2018

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Metabolism of the novel IMP dehydrogenase inhibitor benzamide riboside

21 January 2018

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Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target

21 January 2018

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Targeting signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

2-(3-Amino-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide: a new tiazofurin analogue with potent antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

The macro domain is an ADP-ribose binding module

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Energy coupling in Salmonella typhimurium nicotinic acid phosphoribosyltransferase: identification of His-219 as site of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Indoleamine 2,3 dioxygenase and regulation of T cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Calorie restriction extends yeast life span by lowering the level of NADH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Yeast life-span extension by calorie restriction is independent of NAD fluctuation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Splicing regulates NAD metabolite binding to histone macroH2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A local mechanism mediates NAD-dependent protection of axon degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Neuroprotective strategies in MS: lessons from C57BL/Wld(S) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

NAD+ and NADH in brain functions, brain diseases and brain aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Crystal structure of human kynurenine aminotransferase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Crystal structures of Aedes aegypti kynurenine aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Endogenous kynurenines as targets for drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

The kynurenine pathway of tryptophan degradation as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

IDO expression by dendritic cells: tolerance and tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Prevention of allogeneic fetal rejection by tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Crystal structure of human CD38 extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Visfatin--a true or false trail to type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Glutamine-dependent NAD+Synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

Getting a grip on O-acetyl-ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.695

10.1517/14728222.11.5.695

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference