(Q34003929)

30 July 2017

The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2. (English)

1 reference

30 July 2017

Kendra S Plafker

1

1 reference

30 July 2017

Linda Nguyen

2

1 reference

30 July 2017

Mark Barneche

3

1 reference

30 July 2017

Saima Mirza

4

1 reference

30 July 2017

David Crawford

5

1 reference

30 July 2017

Scott M Plafker

6

1 reference

30 July 2017

language of work or name

English

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publication date

18 May 2010

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30 July 2017

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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30 July 2017

285

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30 July 2017

30

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30 July 2017

23064-23074

1 reference

describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2906300/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation

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Molecular mechanisms of Nrf2-mediated antioxidant response

28 July 2018

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The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.

28 July 2018

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Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

28 July 2018

1 reference

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Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9.

28 July 2018

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Ubc9 interacts with SOX4 and represses its transcriptional activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

28 July 2018

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Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

28 July 2018

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Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

28 July 2018

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

28 July 2018

1 reference

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

28 July 2018

1 reference

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Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import

28 July 2018

1 reference

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

28 July 2018

1 reference

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

28 July 2018

1 reference

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

28 July 2018

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

28 July 2018

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

28 July 2018

1 reference

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A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

28 July 2018

1 reference

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

28 July 2018

1 reference

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

28 July 2018

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Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

28 July 2018

1 reference

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

28 July 2018

1 reference

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Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

28 July 2018

1 reference

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Nrf2 is essential for protection against acute pulmonary injury in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

28 July 2018

1 reference

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hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Identification of a signal for rapid export of proteins from the nucleus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

High-efficiency transformation of mammalian cells by plasmid DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.121913

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906300

29 October 2018

Identifiers

DOI

10.1074/JBC.M110.121913

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aiifujryj5btfbkljspi3mumsy

30 July 2022

release_aiifujryj5btfbkljspi3mumsy

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/aiifujryj5btfbkljspi3mumsy

30 July 2022

https://api.fatcat.wiki/v0/release/aiifujryj5btfbkljspi3mumsy

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30 July 2022

https://api.fatcat.wiki/v0/release/aiifujryj5btfbkljspi3mumsy

1 reference

30 July 2022