(Q46976303)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Subcellular localization and cytoplasmic complex status of endogenous Keap1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

Kelch-like ECH-associated protein 1

8 January 2020

main subject

1 reference

Nuclear factor, erythroid derived 2, like 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Akira Kobayashi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Justina McEvoy

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Yoriko Watai

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Hiroko Nagase

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Mio Mizukami

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Jeffrey D Singer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Ken Itoh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Masayuki Yamamoto

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

1 October 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

1163-1178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17903176%20AND%20SRC:MED&resulttype=core&format=json

The kelch repeat superfamily of proteins: propellers of cell function

8 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

The role of Keap1 in cellular protective responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Axis determination by inhibition of Wnt signaling in Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Constitutive turnover of cyclin E by Cul3 maintains quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Chemoprevention: increased potential to bear fruit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Drosophila kelch is an oligomeric ring canal actin organizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Isolation of rat liver plasma membranes. Use of nucleotide pyrophosphatase and phosphodiesterase I as marker enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

kelch encodes a component of intercellular bridges in Drosophila egg chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2007.01118.X