(Q53616483)

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

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scholarly article

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. (English)

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

1 reference

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Michael McMahon

1

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

5

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Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

author name string

Nerys Thomas

2

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

Ken Itoh

3

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

Masayuki Yamamoto

4

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

language of work or name

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publication date

21 June 2006

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Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

Journal of Biological Chemistry

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Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

281

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Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

24756-24768

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

34

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Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The SCF ubiquitin ligase: insights into a molecular machine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Function and regulation of cullin-RING ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The BACK domain in BTB-kelch proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The kelch repeat superfamily of proteins: propellers of cell function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Crystal structure of the BTB domain from PLZF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Crystal structure of the Kelch domain of human Keap1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601119200

21 January 2018

Identifiers

10.1074/JBC.M601119200

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

1 reference

Europe PubMed Central

16 May 2018

http://europepmc.org/abstract/MED/16790436

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