(Q35691542)

9 August 2017

1 reference

title

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer (English)

1 reference

9 August 2017

Serge Y Fuchs

1

1 reference

9 August 2017

Vladimir S Spiegelman

series ordinal

2

1 reference

9 August 2017

K G Suresh Kumar

series ordinal

3

1 reference

9 August 2017

language of work or name

English

0 references

publication date

1 March 2004

1 reference

9 August 2017

1 reference

9 August 2017

23

1 reference

9 August 2017

2028-2036

1 reference

9 August 2017

11

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207389

9 August 2017

0 references

cites work

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The Xenopus laevis beta TrCP gene: genomic organization, alternative splicing, 5' and 3' region characterization and comparison of its structure with that of human beta TrCP genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Nuclear factor-kappa B and cancer: its role in prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Constitutively active NFkappa B is required for the survival of S-type neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Identification of a family of human F-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

A protein knockdown strategy to study the function of beta-catenin in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Evidence that reactive oxygen species do not mediate NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

NF-kappaB and cell-cycle regulation: the cyclin connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Regulation of beta-catenin function by the IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Substrate targeting in the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The oncogenic activation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The precursor of NF-kappa B p50 has I kappa B-like functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Nf-kappa B, chemokine gene transcription and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Structure, regulation and function of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Inhibition of HOS expression and activities by Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Themes and variations on ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

A family of mammalian F-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

Pyrrolidinedithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

7 January 2021

Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

7 January 2021

Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

7 January 2021

Sacrosine- and prolinedithiocarbamate pretreatment increases the therapeutic efficacy of doxorubicin, methotrexate, teniposide, mitoxantrone or cyclohexylchloroethylnitrosourea in leukemia L1210

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

7 January 2021

In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207389

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207389

1 reference

9 August 2017

1 reference