(Q40927249)

24 September 2017

title

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. (English)

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24 September 2017

main subject

protein ubiquitination

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based on heuristic

inferred from title

author

Shigetsugu Hatakeyama

2

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24 September 2017

Shirane M

1

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24 September 2017

Hattori K

3

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24 September 2017

Nakayama K

4

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24 September 2017

Nakayama K

5

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24 September 2017

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

274

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24 September 2017

issue

40

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24 September 2017

page(s)

28169-28174

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Signal transduction through NF-kappa B.

24 September 2017

cites work

1 reference

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Mechanisms by which IkappaB proteins control NF-kappaB activity

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Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

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The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

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Autoregulation of I kappa B alpha activity

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I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

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Cloning and functional characterization of mouse IkappaBepsilon

21 January 2018

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NF-kappa B subunit-specific regulation of the interleukin-8 promoter

21 January 2018

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21 January 2018

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

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Identification and characterization of an IkappaB kinase

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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21 January 2018

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21 January 2018

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Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

21 January 2018

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

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The ubiquitin system for protein degradation

21 January 2018

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Regulating protein degradation by ubiquitination

21 January 2018

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Proteolysis and the G1-S transition: the SCF connection

21 January 2018

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

21 January 2018

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Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.40.28169

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

21 January 2018

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Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.40.28169

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.40.28169

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.40.28169

Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.40.28169

21 January 2018

Identifiers

DOI

10.1074/JBC.274.40.28169

1 reference

24 September 2017

1 reference