(Q36642707)

15 August 2017

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title

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism (English)

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15 August 2017

Kit I Tong

1

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15 August 2017

Akira Kobayashi

series ordinal

2

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15 August 2017

Fumiki Katsuoka

series ordinal

3

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15 August 2017

Masayuki Yamamoto

series ordinal

4

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15 August 2017

1 October 2006

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15 August 2017

1 reference

15 August 2017

387

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15 August 2017

1311-1320

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15 August 2017

10-11

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Mitochondrial regulation of oxygen sensing

15 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The ubiquitin system: pathogenesis of human diseases and drug targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Molecular pathways in virus-induced cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Strategies of antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Electrostatic influence of local cysteine environments on disulfide exchange kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The BACK domain in BTB-kelch proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Sequence and structural analysis of BTB domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2006.164

21 January 2018

Identifiers

DOI

10.1515/BC.2006.164

1 reference

15 August 2017

1 reference