(Q40815579)

24 September 2017

title

Rac1 activity is required for the activation of hypoxia-inducible factor 1. (English)

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24 September 2017

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2

G L Semenza

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24 September 2017

K Hirota

1

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24 September 2017

language of work or name

English

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publication date

30 March 2001

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

276

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24 September 2017

issue

24

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24 September 2017

page(s)

21166-21172

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

24 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100677200

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100677200

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

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Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

21 January 2018

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Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

21 January 2018

1 reference

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

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Perspectives on oxygen sensing

21 January 2018

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Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

21 January 2018

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Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway

21 January 2018

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Association of calcium channel alpha1S and beta1a subunits is required for the targeting of beta1a but not of alpha1S into skeletal muscle triads

21 January 2018

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

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Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

21 January 2018

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

21 January 2018

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Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

21 January 2018

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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

21 January 2018

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

21 January 2018

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NAD(P)H oxidase: role in cardiovascular biology and disease

21 January 2018

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Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1, and CREB activation in HEK293 cells.

21 January 2018

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Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1

21 January 2018

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

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Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

21 January 2018

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

21 January 2018

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Protection from reoxygenation injury by inhibition of rac1.

21 January 2018

1 reference

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100677200

The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M100677200

Identifiers

DOI

10.1074/JBC.M100677200

1 reference

24 September 2017

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