(Q34004838)

30 July 2017

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title

Strategies to improve drug delivery across the blood-brain barrier (English)

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30 July 2017

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Albertus G de Boer

1

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30 July 2017

Pieter J Gaillard

series ordinal

2

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30 July 2017

language of work or name

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1 January 2007

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Clinical Pharmacokinetics

30 July 2017

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30 July 2017

46

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30 July 2017

7

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30 July 2017

553-576

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https://scigraph.springernature.com/pub.10.2165/00003088-200746070-00002

30 July 2017

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cites work

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200746070-00002

Regional distribution of heparin-binding epidermal growth factor-like growth factor mRNA and protein in adult rat forebrain.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200746070-00002

Reducing the immunostimulatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy

21 January 2018

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12 December 2020

Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery

1 reference

12 December 2020

Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes

1 reference

12 December 2020

The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain.

1 reference

12 December 2020

Heparin-binding epidermal growth factor-like growth factor in hippocampus: modulation of expression by seizures and anti-excitotoxic action

1 reference

12 December 2020

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

1 reference

12 December 2020

Cell-specific targeting of lipid-based carriers for ODN and DNA.

1 reference

12 December 2020

The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type

1 reference

12 December 2020

Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

1 reference

12 December 2020

Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two-photon fluorescence correlation spectroscopy

1 reference

12 December 2020

Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

1 reference

12 December 2020

New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy.

1 reference

12 December 2020

The transferrin receptor: role in health and disease

1 reference

12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

12 December 2020

What is the blood-brain barrier (not)?

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12 December 2020

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

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12 December 2020

Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

1 reference

12 December 2020

Proteolysis: from the lysosome to ubiquitin and the proteasome

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12 December 2020

Immune protection of the brain--efficient and delicate

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12 December 2020

A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier

1 reference

12 December 2020

A Toll-like receptor recognizes bacterial DNA

1 reference

12 December 2020

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

1 reference

12 December 2020

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

1 reference

12 December 2020

Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy

1 reference

12 December 2020

Blood-brain barrier transcytosis of insulin in developing rabbits

1 reference

12 December 2020

Structural and functional aspects of the blood-brain barrier.

1 reference

12 December 2020

The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells

1 reference

12 December 2020

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

1 reference

12 December 2020

Beta-amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats.

1 reference

12 December 2020

Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration

1 reference

12 December 2020

Drug targeting. Breaking down barriers.

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12 December 2020

Nanoparticle surface charges alter blood-brain barrier integrity and permeability

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12 December 2020

Caveolae: an alternative membrane transport compartment

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12 December 2020

Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery

1 reference

12 December 2020

Brain cancer diagnosis and therapy with nanoplatforms

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12 December 2020

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

1 reference

12 December 2020

Role of the CNS microvascular pericyte in the blood-brain barrier

1 reference

12 December 2020

Poly(ethylenimine) and its role in gene delivery

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12 December 2020

Inflammatory mediators and modulation of blood-brain barrier permeability

1 reference

12 December 2020

Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means

1 reference

12 December 2020

Targeting of polyplexes: toward synthetic virus vector systems

1 reference

12 December 2020

Mechanistic studies of sequential injection of cationic liposome and plasmid DNA.

1 reference

12 December 2020

Intravascular ultrasound molecular imaging of atheroma components in vivo.

1 reference

12 December 2020

Controlling the kinetics of transgene expression by plasmid design

1 reference

12 December 2020

Ultrasound-induced cavitation: applications in drug and gene delivery

1 reference

12 December 2020

Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

1 reference

12 December 2020

Behavior of the N-terminal helices of the diphtheria toxin T domain during the successive steps of membrane interaction

1 reference

12 December 2020

Are the extracellular [correction of extracelluar] pathways a conduit for the delivery of therapeutics to the brain?

1 reference

12 December 2020

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury.

1 reference

12 December 2020

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

1 reference

12 December 2020

Drug delivery to damaged brain

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12 December 2020

Transporters and drug therapy: implications for drug disposition and disease

1 reference

12 December 2020

Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3.

1 reference

12 December 2020

EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice

1 reference

12 December 2020

Human gene therapy and imaging in neurological diseases

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12 December 2020

Receptor mediated uptake of peptides that bind the human transferrin receptor

1 reference

12 December 2020

The blood-brain barrier in neuroinflammatory diseases

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12 December 2020

Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus

1 reference

12 December 2020

The cell biology of the blood-brain barrier.

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12 December 2020

Polycation-based DNA complexes for tumor-targeted gene delivery in vivo

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12 December 2020

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

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12 December 2020

Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound

1 reference

12 December 2020

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.

1 reference

12 December 2020

Welcome to the nucleus: CAN I take your coat?

1 reference

12 December 2020

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

1 reference

12 December 2020

Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels

1 reference

12 December 2020

The blood-brain barrier/neurovascular unit in health and disease

1 reference

12 December 2020

Brain endothelial hemostasis regulation by pericytes

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12 December 2020

The role of blood-brain barrier studies in the pharmaceutical industry

1 reference

12 December 2020

Expression of leptin receptor isoforms in rat brain microvessels.

1 reference

12 December 2020

Rapid transferrin efflux from brain to blood across the blood-brain barrier

1 reference

12 December 2020

Molecular biology of the blood-brain barrier

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12 December 2020

Enhanced local delivery with reduced systemic toxicity: delivery, delivery, and delivery.

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12 December 2020

Transporter-mediated permeation of drugs across the blood-brain barrier

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12 December 2020

Active targeting with particulate drug carriers in tumor therapy: fundamentals and recent progress

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12 December 2020

The critical component to establish in vitro BBB model: Pericyte

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12 December 2020

Strategies to optimize brain penetration in drug discovery.

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12 December 2020

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

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12 December 2020

Degradable gene carriers based on oligomerized polyamines

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12 December 2020

Heparin-binding EGF-like growth factor

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12 December 2020

Tumor targeting with surface-shielded ligand--polycation DNA complexes.

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12 December 2020

Receptor-mediated gene delivery and expression in vivo.

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12 December 2020

A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery

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12 December 2020

Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration

1 reference

12 December 2020

LRP: a multifunctional scavenger and signaling receptor

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12 December 2020

Transport systems for opioid peptides in mammalian tissues

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12 December 2020

Dynamics of CNS barriers: evolution, differentiation, and modulation

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12 December 2020

Glucose-receptor MR imaging of tumors: study in mice with PEGylated paramagnetic niosomes

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12 December 2020

The role of drug transporters at the blood-brain barrier

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12 December 2020

Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Human blood-brain barrier transferrin receptor

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12 December 2020

Seizure-promoting effect of blood-brain barrier disruption

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12 December 2020

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

1 reference

12 December 2020

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

1 reference

12 December 2020

Characterization and modulation of the transferrin receptor on brain capillary endothelial cells

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12 December 2020

Cell-penetrating peptides: a comparative membrane toxicity study

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12 December 2020

Drug and gene targeting to the brain with molecular Trojan horses

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12 December 2020

Tumor-targeted gene transfer with DNA polyplexes

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12 December 2020

Pharmaceutical applications of magnetic resonance imaging (MRI).

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12 December 2020

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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12 December 2020

Astrocytes induce blood–brain barrier properties in endothelial cells

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12 December 2020

DNA polyplexes based on degradable oligoethylenimine-derivatives: combination with EGF receptor targeting and endosomal release functions

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12 December 2020

Targeted contrast agents for magnetic resonance imaging and ultrasound

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12 December 2020

Intracellular routing of plasmid DNA during non-viral gene transfer.

1 reference

12 December 2020

Ultracytochemical characterization of anionic sites in the wall of brain capillaries.

1 reference

12 December 2020

Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

1 reference

12 December 2020

A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA.

1 reference

12 December 2020

Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response

1 reference

12 December 2020

Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197.

1 reference

12 December 2020

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

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12 December 2020

Drug targeting with nano-sized carrier systems

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12 December 2020

Drug resistance in brain diseases and the role of drug efflux transporters.

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12 December 2020

New transport peptides broaden the horizon of applications for peptidic pharmaceuticals.

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12 December 2020

Gene therapy with viral vectors

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12 December 2020

Transporting therapeutics across the blood-brain barrier

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12 December 2020

Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells

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12 December 2020

A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells

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12 December 2020

Recent approaches to intracellular delivery of drugs and DNA and organelle targeting

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12 December 2020

Fine structural localization of a blood-brain barrier to exogenous peroxidase

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12 December 2020

Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

1 reference

12 December 2020

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier

1 reference

12 December 2020

Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials

1 reference

12 December 2020

Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv

1 reference

12 December 2020

Anorectic effects of circulating cytokines: role of the vascular blood-brain barrier

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12 December 2020

Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity

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12 December 2020

Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain.

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12 December 2020

CRM197 (nontoxic diphtheria toxin): effects on advanced cancer patients

1 reference

12 December 2020

High transcytosis of melanotransferrin (P97) across the blood-brain barrier

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12 December 2020

Human blood-brain barrier insulin-like growth factor receptor

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12 December 2020

Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity

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12 December 2020

Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids.

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12 December 2020

Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain

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12 December 2020

Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier.

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12 December 2020

Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide.

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12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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12 December 2020

The multidrug resistance protein family.

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12 December 2020

Drug targeting to the brain.

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12 December 2020

Theoretical considerations involving the pharmacokinetics of plasmid DNA.

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12 December 2020

Targeted gene transfer to nigrostriatal neurons in the rat brain by helper virus-free HSV-1 vector particles that contain either a chimeric HSV-1 glycoprotein C-GDNF or a gC-BDNF protein

1 reference

12 December 2020

LRP: role in vascular wall integrity and protection from atherosclerosis

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro

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12 December 2020

Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer

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12 December 2020

Transcytosis of protein through the mammalian cerebral epithelium and endothelium. III. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin receptor.

1 reference

12 December 2020

Cell-penetrating peptides.

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12 December 2020

Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse

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12 December 2020

Delivery of bioactive molecules into the cell: the Trojan horse approach

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12 December 2020

Polyethylenimine-based non-viral gene delivery systems

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12 December 2020

Gene medicines: the end of the beginning?

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12 December 2020

Development of neuropeptide drugs that cross the blood-brain barrier

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12 December 2020

Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7.

1 reference

12 December 2020

Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery.

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12 December 2020

Junctions between intimately apposed cell membranes in the vertebrate brain

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12 December 2020

Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously

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12 December 2020

Drug delivery to brain and the role of carrier-mediated transport.

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12 December 2020

Liposomes: conquering the nuclear barrier

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12 December 2020

Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

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12 December 2020

Transferrin and transferrin receptor function in brain barrier systems

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12 December 2020

Targeting liposomes with protein drugs to the blood-brain barrier in vitro

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12 December 2020

Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury.

1 reference

12 December 2020

Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries

1 reference

12 December 2020

The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain

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12 December 2020

Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface

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12 December 2020

Regulated portals of entry into the cell

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12 December 2020

Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin

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12 December 2020

Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat.

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12 December 2020

Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas

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12 December 2020

Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture

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12 December 2020

Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes

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12 December 2020

10.2165/00003088-200746070-00002

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

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