(Q33988704)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

review article

1 reference

title

Drug resistance in brain diseases and the role of drug efflux transporters (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Wolfgang Löscher

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

language of work or name

English

0 references

publication date

1 August 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Neuroscience

31 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

591-602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrn1728

31 December 2019

exact match

0 references

cites work

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21 January 2018

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21 January 2018

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Pharmacogenomics in cancer therapy: is host genome variability important?

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21 January 2018

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Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

21 January 2018

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Anti-HIV drug distribution to the central nervous system

21 January 2018

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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

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Multidrug resistance: molecular mechanisms and clinical relevance

21 January 2018

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Importance of P-glycoprotein at blood-tissue barriers

21 January 2018

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beta-Amyloid efflux mediated by p-glycoprotein

21 January 2018

1 reference

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.

21 January 2018

1 reference

Altered P-glycoprotein expression in AIDS patients with HIV encephalitis

21 January 2018

1 reference

Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

21 January 2018

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Drug transport at the blood-brain barrier and the choroid plexus

21 January 2018

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The blood-brain barrier: bottleneck in brain drug development

21 January 2018

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Astrocyte-endothelial interactions and blood-brain barrier permeability

21 January 2018

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Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

21 January 2018

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ABC transporters and the blood-brain barrier

21 January 2018

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

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Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

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Drug efflux transporters in the CNS.

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

1 reference

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

DNA-microarray analysis of brain cancer: molecular classification for therapy

21 January 2018

1 reference

Modulation of drug transporters at the blood-brain barrier

21 January 2018

1 reference

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice

21 January 2018

1 reference

HIV-infection of the central nervous system: the tightrope walk of innate immunity

21 January 2018

1 reference

GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats

21 January 2018

1 reference

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

21 January 2018

1 reference

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

21 January 2018

1 reference

Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2).

21 January 2018

1 reference

The neurobiology of antiepileptic drugs

21 January 2018

1 reference

Early identification of refractory epilepsy

21 January 2018

1 reference

Mechanisms of antiepileptic drug resistance

21 January 2018

1 reference

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

21 January 2018

1 reference

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

1 reference

In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

21 January 2018

1 reference

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

21 January 2018

1 reference

P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

21 January 2018

1 reference

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

21 January 2018

1 reference

Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

1 reference

Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections.

21 January 2018

1 reference

Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

21 January 2018

1 reference

Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats.

21 January 2018

1 reference

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

21 January 2018

1 reference

Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats

21 January 2018

1 reference

Clinical aspects and biological bases of drug-resistant epilepsies

21 January 2018

1 reference

Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

21 January 2018

1 reference

A novel mechanism underlying drug resistance in chronic epilepsy

21 January 2018

1 reference

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

21 January 2018

1 reference

Definition and epidemiology of treatment-resistant depression

21 January 2018

1 reference

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

21 January 2018

1 reference

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

21 January 2018

1 reference

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

21 January 2018

1 reference

21 January 2018

1 reference

In vitro P-glycoprotein affinity for atypical and conventional antipsychotics

21 January 2018

1 reference

Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates

21 January 2018

1 reference

Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals

21 January 2018

1 reference

The potential management of resistant infections with non-antibiotics

21 January 2018

1 reference

Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo.

21 January 2018

1 reference

Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy.

21 January 2018

1 reference

Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol

21 January 2018

1 reference

Uptake of clozapine into HL-60 promyelocytic leukaemia cells

21 January 2018

1 reference

Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.

21 January 2018

1 reference

PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS.

21 January 2018

1 reference

Brain drug delivery of small molecules using immunoliposomes

21 January 2018

1 reference

By-passing of P-glycoprotein using immunoliposomes

21 January 2018

1 reference

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

Promiscuous regulator of xenobiotic removal

21 January 2018

1 reference

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

Orphan nuclear receptor modulators

21 January 2018

1 reference

Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

21 January 2018

1 reference

21 January 2018

1 reference

Seizure-induced neuronal injury: animal data

21 January 2018

1 reference

Glutamate as a therapeutic target in psychiatric disorders

21 January 2018

1 reference

Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.

21 January 2018

1 reference

Endothelin peptides in brain diseases

21 January 2018

1 reference

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

21 January 2018

1 reference

Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).

21 January 2018

1 reference

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

1 reference

Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene

21 January 2018

1 reference

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

21 January 2018

1 reference

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

1 reference

Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

21 January 2018

1 reference

Is the multidrug transporter a flippase?

21 January 2018

1 reference

The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

1 reference

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

1 reference

Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain

21 January 2018

1 reference

Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity

21 January 2018

1 reference

Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.

21 January 2018

1 reference

21 January 2018

1 reference

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

Multidrug resistance--a multiplex phenomenon

21 January 2018

1 reference

Current status and future directions in the pharmacotherapy of epilepsy

31 March 2020

1 reference

The impact of efflux transporters in the brain on the development of drugs for CNS disorders

31 March 2020

1 reference

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.

31 March 2020

1 reference

New horizons in the development of antiepileptic drugs: the search for new targets.

31 March 2020

1 reference

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

31 March 2020

1 reference

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease.

31 March 2020

1 reference

Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.

31 March 2020

1 reference

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

31 March 2020

1 reference

Multidrug resistance in brain tumors: roles of the blood-brain barrier

31 March 2020

1 reference

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

31 March 2020

1 reference

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

31 March 2020

1 reference

31 March 2020

1 reference

The consequences of uncontrolled epilepsy.

31 March 2020

1 reference

MDR1 gene expression in brain of patients with medically intractable epilepsy

31 March 2020

1 reference

Over-expression of P-glycoprotein in malformations of cortical development.

31 March 2020

1 reference

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

31 March 2020

1 reference

Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

31 March 2020

1 reference

Perioperative Untersuchungen in der Epilepsiechirurgie - Eine Einführung

31 March 2020

1 reference

Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy

31 March 2020

1 reference

Prevalence and incidence studies of mood disorders: a systematic review of the literature

31 March 2020

1 reference

Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier

31 March 2020

1 reference

Treatment-resistant schizophrenia--the role of clozapine

31 March 2020

1 reference

Modulation of p-glycoprotein transport function at the blood-brain barrier

31 March 2020

1 reference

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

31 March 2020

1 reference

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

31 March 2020

1 reference

Glutamate in CNS disorders as a target for drug development: an update

31 March 2020

1 reference

The brain endothelin system as potential target for brain-related pathologies

31 March 2020

1 reference

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

31 March 2020

1 reference

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

31 March 2020

1 reference

Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

31 March 2020

1 reference

Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

31 March 2020

1 reference

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

31 March 2020

1 reference

Clozapine versus typical neuroleptic medication for schizophrenia

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN1728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025095%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 December 2019

0 references

1 reference