(Q34514599)

2 August 2017

title

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo (English)

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2 August 2017

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13

T Hartmann

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2 August 2017

K Fassbender

1

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2 August 2017

M Simons

2

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2 August 2017

C Bergmann

3

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2 August 2017

M Stroick

4

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2 August 2017

D Lutjohann

5

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2 August 2017

P Keller

6

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2 August 2017

H Runz

7

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2 August 2017

S Kuhl

8

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2 August 2017

T Bertsch

9

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2 August 2017

K von Bergmann

10

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2 August 2017

M Hennerici

11

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2 August 2017

K Beyreuther

12

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2 August 2017

language of work or name

English

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publication date

10 April 2001

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

98

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2 August 2017

issue

10

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2 August 2017

page(s)

5856-5861

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A simple method for the isolation and purification of total lipides from animal tissues

2 August 2017

cites work

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

7 July 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

7 July 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

7 July 2018

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

7 July 2018

1 reference

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Functional rafts in cell membranes

7 July 2018

1 reference

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

7 July 2018

1 reference

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The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein

7 July 2018

1 reference

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

7 July 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 July 2018

1 reference

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Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.

7 July 2018

1 reference

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Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

7 July 2018

1 reference

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

7 July 2018

1 reference

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Hypocholesteremia induced by orotic acid: dietary effects and species specificity

7 July 2018

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Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

A simplified micro-method for quantification of fecal excretion of neutral and acidic sterols for outpatient studies in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Amyloid beta-peptide is produced by cultured cells during normal metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Influence of lipid profile and fatty acid composition on the oxidation behavior of rat and guinea pig low density lipoprotein.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Semliki Forest virus as a tool for protein expression in cultured rat hippocampal neurons.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Evidence that Aβ42 is the real culprit in alzheimer's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

The density profile and cholesterol concentration of serum lipoproteins in domestic and laboratory animals.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33303

Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7alpha-hydroxylase activities in the rat, guinea pig, and rabbit: effects of cholesterol and bile acids

27 October 2018

1 reference

12 December 2020

Intracellular trafficking of cholesterol monitored with a cyclodextrin

1 reference

12 December 2020

Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population

1 reference

12 December 2020

Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study

1 reference

12 December 2020

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.081620098

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2 August 2017

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2 August 2017

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