(Q34558556)

3 August 2017

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title

The impact of efflux transporters in the brain on the development of drugs for CNS disorders (English)

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3 August 2017

Eve M Taylor

1

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3 August 2017

publication date

1 January 2002

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Clinical Pharmacokinetics

3 August 2017

published in

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3 August 2017

volume

41

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3 August 2017

issue

2

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3 August 2017

page(s)

81-92

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https://scigraph.springernature.com/pub.10.2165/00003088-200241020-00001

3 August 2017

exact match

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cites work

Zidovudine transport within the rabbit brain during intracerebroventricular administration and the effect of probenecid.

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12 December 2020

Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine

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12 December 2020

Monocarboxylate transporter expression in mouse brain

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12 December 2020

Factors affecting distribution of iodide in brain and cerebrospinal fluid.

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12 December 2020

New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy.

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12 December 2020

Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.

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12 December 2020

SPINAL FLUID IODIDE TRANSPORT IN THE DOG.

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12 December 2020

Inhibitors of multidrug resistance.

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12 December 2020

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

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12 December 2020

pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells

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12 December 2020

MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors.

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12 December 2020

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

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12 December 2020

Leukotriene C4 transport and metabolism in the central nervous system.

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12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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12 December 2020

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

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12 December 2020

Exchange of cerebrospinal fluid potassium with blood and brain. Study in normal and Ouabain perfused cats.

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12 December 2020

Expression of the monocarboxylate transporter MCT2 by rat brain glia.

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12 December 2020

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system

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12 December 2020

Major vault protein LRP-related multidrug resistance

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12 December 2020

Influence of various drugs on the transport of 131I and PAH across the cerebrospinal‐fluid—blood barrier

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12 December 2020

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

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12 December 2020

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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12 December 2020

Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain.

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12 December 2020

Transport of GABA at the blood-CSF interface

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12 December 2020

Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

1 reference

12 December 2020

Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study.

1 reference

12 December 2020

Potassium exchange between cerebrospinal fluid, plasma, and brain

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12 December 2020

Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta

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12 December 2020

Dichotomous development of the organic anion transport protein in liver and choroid plexus.

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12 December 2020

Blood-brain barrier transport of valproic acid.

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12 December 2020

Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood

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12 December 2020

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

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12 December 2020

Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters

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12 December 2020

Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells.

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12 December 2020

MDR1 gene expression in brain of patients with medically intractable epilepsy

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12 December 2020

Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit

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12 December 2020

What is the blood-brain barrier? A molecular perspective. Cerebral vascular biology.

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12 December 2020

Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux.

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12 December 2020

Xenobiotic transport across isolated brain microvessels studied by confocal microscopy

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12 December 2020

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

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12 December 2020

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Blood-Brain and CSF Barriers to Penicillin and Related Organic Acids

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12 December 2020

Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine

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12 December 2020

Organic cation transporters in intestine, kidney, liver, and brain

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12 December 2020

Rapid efflux of some quaternary ammonium compounds from cerebrospinal fluid

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12 December 2020

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells

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12 December 2020

P-glycoprotein and multidrug resistance

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12 December 2020

Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter

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12 December 2020

Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis.

1 reference

12 December 2020

cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter.

1 reference

12 December 2020

Comparisons of P‐glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta

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12 December 2020

Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

1 reference

12 December 2020

Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1

1 reference

12 December 2020

The multispecific organic anion transporter (OAT) family.

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12 December 2020

A novel transmembrane transporter encoded by the XPCT gene in Xq13.2

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12 December 2020

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

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12 December 2020

Aluminum citrate is transported from brain into blood via the monocarboxylic acid transporter located at the blood-brain barrier.

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12 December 2020

Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation

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12 December 2020

Molecular and functional characterization of organic cation/carnitine transporter family in mice

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12 December 2020

Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.

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12 December 2020

Brain microvascular and astrocyte localization of P-glycoprotein.

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12 December 2020

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

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12 December 2020

Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes.

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12 December 2020

Cellular and molecular aspects of drug transport in the kidney

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12 December 2020

Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2

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12 December 2020

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Multidrug resistance and its reversal

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12 December 2020

Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

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12 December 2020

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1 reference

12 December 2020

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1 reference

12 December 2020

Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

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12 December 2020

Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system

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12 December 2020

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier.

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12 December 2020

P-glycoprotein of blood brain barrier: cross-reactivity of Mab C219 with a 190 kDa protein in bovine and rat isolated brain capillaries

1 reference

12 December 2020

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines

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12 December 2020

Expression, transport properties, and chromosomal location of organic anion transporter subtype 3

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12 December 2020

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

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12 December 2020

Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans

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12 December 2020

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

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12 December 2020

Cellular localization of P-glycoprotein in brain versus gonadal capillaries

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12 December 2020

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

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12 December 2020

High levels of P-glycoprotein detected in isolated brain capillaries.

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12 December 2020

The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain

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12 December 2020

Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

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12 December 2020

Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates.

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12 December 2020

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

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12 December 2020

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

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12 December 2020

Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier

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12 December 2020

Microdialysis study of zidovudine (AZT) transport in rat brain.

1 reference

12 December 2020

Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain

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12 December 2020

Evidence of active transport of benzyl-14C-penicillin from cerebrospinal fluid to blood.

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12 December 2020

Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese hamster.

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12 December 2020

Aluminum transport out of brain extracellular fluid is proton dependent and inhibited by mersalyl acid, suggesting mediation by the monocarboxylate transporter (MCT1).

1 reference

12 December 2020

Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.

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12 December 2020

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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12 December 2020

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

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12 December 2020

Functional expression of the P-glycoprotein mdr in primary cultures of bovine cerebral capillary endothelial cells

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12 December 2020

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

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12 December 2020

In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.

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12 December 2020

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

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12 December 2020

Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitors

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12 December 2020

Functional involvement of P-glycoprotein in blood-brain barrier

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12 December 2020

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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12 December 2020

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

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12 December 2020

Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4.

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12 December 2020

The multidrug resistance protein family.

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12 December 2020

The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicyclic acid and iodide

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12 December 2020

Transport of lactate and other monocarboxylates across mammalian plasma membranes

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12 December 2020

Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates.

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12 December 2020

Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

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12 December 2020

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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12 December 2020

Effect of para-aminohippurate on the efflux of valproic acid from the central nervous system of the rabbit.

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12 December 2020

Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier.

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12 December 2020

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage

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12 December 2020

Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line

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12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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12 December 2020

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

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12 December 2020

Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro.

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12 December 2020

Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine

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12 December 2020

Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

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12 December 2020

Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

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12 December 2020

Cloning and functional expression of a human liver organic cation transporter

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12 December 2020

The P-glycoprotein efflux pump: how does it transport drugs?

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12 December 2020

Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system.

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12 December 2020

Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP

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12 December 2020

Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain

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12 December 2020

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

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12 December 2020

10.2165/00003088-200241020-00001

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1003342304

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