(Q35607530)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

review article

1 reference

title

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Hongbing Wang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

language of work or name

1 reference

1 January 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacokinetics

22 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

1331-1357

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.2165/00003088-200342150-00003

22 December 2019

exact match

0 references

cites work

Regulation of the mevalonate pathway

1 reference

12 December 2020

Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors

1 reference

12 December 2020

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

1 reference

12 December 2020

FXR, a bile acid receptor and biological sensor

1 reference

12 December 2020

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

12 December 2020

Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells

1 reference

12 December 2020

The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver.

1 reference

12 December 2020

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation

1 reference

12 December 2020

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1 reference

12 December 2020

Orphan nuclear receptors--new ligands and new possibilities.

1 reference

12 December 2020

A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

1 reference

12 December 2020

Misdiagnosis of Cushing's syndrome in a patient receiving rifampicin therapy for tuberculosis.

1 reference

12 December 2020

The steroid and thyroid hormone receptor superfamily

1 reference

12 December 2020

Abnormal overnight dexamethasone suppression test in subjects receiving rifampicin therapy

1 reference

12 December 2020

Analysis of peroxisome proliferator-responsive enhancer of the rat acyl-CoA oxidase gene

1 reference

12 December 2020

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

1 reference

12 December 2020

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

12 December 2020

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

1 reference

12 December 2020

Nucleocytoplasmic shuttling of the progesterone receptor

1 reference

12 December 2020

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

1 reference

12 December 2020

Identification of a nuclear receptor for bile acids

1 reference

12 December 2020

Identification of a nuclear receptor that is activated by farnesol metabolites

1 reference

12 December 2020

Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones

1 reference

12 December 2020

Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers

1 reference

12 December 2020

Localization of the Rev-ErbA orphan receptors in the brain.

1 reference

12 December 2020

PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

1 reference

12 December 2020

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

1 reference

12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

1 reference

12 December 2020

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

12 December 2020

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

1 reference

12 December 2020

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

12 December 2020

Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation.

1 reference

12 December 2020

Orphan nuclear receptors: the exotics of xenobiotics.

1 reference

12 December 2020

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

1 reference

12 December 2020

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

12 December 2020

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

1 reference

12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

1 reference

12 December 2020

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

1 reference

12 December 2020

Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators

1 reference

12 December 2020

A unified nomenclature system for the nuclear receptor superfamily

1 reference

12 December 2020

Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis

1 reference

12 December 2020

Multiple oxidants in cytochrome P450 catalyzed reactions: implications for drug metabolism

1 reference

12 December 2020

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

12 December 2020

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

1 reference

12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

12 December 2020

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in man: relationship to glucocorticoid receptors.

1 reference

12 December 2020

Herb-drug interactions: review and assessment of report reliability

1 reference

12 December 2020

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

12 December 2020

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA

1 reference

12 December 2020

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

1 reference

12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

12 December 2020

The effects of therapy with rifampicin and isoniazid on basic investigations for Cushing's syndrome

1 reference

12 December 2020

Peroxisome proliferator-activated receptors: structures and function

1 reference

12 December 2020

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

1 reference

12 December 2020

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

1 reference

12 December 2020

A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

1 reference

12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

12 December 2020

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

1 reference

12 December 2020

Predicting chemotherapy response and comparing with P-glycoprotein expression using technetium-99m tetrofosmin scan in untreated malignant lymphomas

1 reference

12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

12 December 2020

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

1 reference

12 December 2020

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

1 reference

12 December 2020

Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

1 reference

12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

12 December 2020

Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

1 reference

12 December 2020

Possible role for vitamin D in controlling breast cancer cell proliferation

1 reference

12 December 2020

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

1 reference

12 December 2020

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

1 reference

12 December 2020

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

1 reference

12 December 2020

Nuclear receptor that identifies a novel retinoic acid response pathway

1 reference

12 December 2020

LXR, a nuclear receptor that defines a distinct retinoid response pathway

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

1 reference

12 December 2020

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1 reference

12 December 2020

The nuclear receptor superfamily: the second decade

1 reference

12 December 2020

Biochemical and molecular aspects of genetic disorders of bilirubin metabolism

1 reference

12 December 2020

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

12 December 2020

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site

1 reference

12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

12 December 2020

Principles and practice of HIV-protease inhibitor pharmacoenhancement

1 reference

12 December 2020

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1 reference

12 December 2020

Novel sequence determinants in peroxisome proliferator signaling

1 reference

12 December 2020

Glucocorticoid receptors on mononuclear leukocytes in Alzheimer's disease

1 reference

12 December 2020

Second thoughts about safety of St John's wort

1 reference

12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

1 reference

12 December 2020

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver

1 reference

12 December 2020

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

1 reference

12 December 2020

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

12 December 2020

Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation

1 reference

12 December 2020

Autoregulation of the human liver X receptor alpha promoter

1 reference

12 December 2020

Using inducible vectors to study intracellular trafficking of GFP-tagged steroid/nuclear receptors in living cells

1 reference

12 December 2020

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

1 reference

12 December 2020

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

1 reference

12 December 2020

CYP3A genetics in drug metabolism

1 reference

12 December 2020

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

12 December 2020

Transcriptional regulation of gene expression during adipocyte differentiation

1 reference

12 December 2020

Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents

1 reference

12 December 2020

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

12 December 2020

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism

1 reference

12 December 2020

P450IIB gene expression in rat small intestine: cloning of intestinal P450IIB1 mRNA using the polymerase chain reaction and transcriptional regulation of induction

1 reference

12 December 2020

Cholesterol homeostasis: a role for oxysterols.

1 reference

12 December 2020

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1 reference

12 December 2020

Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding

1 reference

12 December 2020

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

1 reference

12 December 2020

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity

1 reference

12 December 2020

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

12 December 2020

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

12 December 2020

Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators

1 reference

12 December 2020

Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity

1 reference

12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

1 reference

12 December 2020

The continuing importance of bile acids in liver and intestinal disease

1 reference

12 December 2020

Therapeutic outcome and side-effects after radiotherapy, chemotherapy and/or hyperthermia treatment of head and neck tumour xenografts

1 reference

12 December 2020

Nuclear hormone receptors activate direct, inverted, and everted repeats.

1 reference

12 December 2020

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

1 reference

12 December 2020

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

12 December 2020

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1 reference

12 December 2020

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

12 December 2020

Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice

1 reference

12 December 2020

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

12 December 2020

The effect of rifampin treatment on intestinal expression of human MRP transporters

1 reference

12 December 2020

The nuclear receptor ligand-binding domain: structure and function

1 reference

12 December 2020

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

1 reference

12 December 2020

Orphan nuclear receptors: from gene to function

1 reference

12 December 2020

The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling

1 reference

12 December 2020

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes

1 reference

12 December 2020

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

12 December 2020

The LXRs: a new class of oxysterol receptors

1 reference

12 December 2020

The peroxisome proliferator-activated receptor: transcriptional activation of the CYP4A6 gene

1 reference

12 December 2020

Increasing the complexity of coactivation in nuclear receptor signaling

1 reference

12 December 2020

Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors

1 reference

12 December 2020

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

1 reference

12 December 2020

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

1 reference

12 December 2020

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms

1 reference

12 December 2020

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

1 reference

12 December 2020

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

1 reference

12 December 2020

Retinoid receptors in development and disease.

1 reference

12 December 2020

Role of drug metabolism in drug discovery and development

1 reference

12 December 2020

Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the li

1 reference

12 December 2020

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

12 December 2020

Use of the nuclear receptor PXR to predict drug interactions

1 reference

12 December 2020

The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs

1 reference

12 December 2020

Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics

1 reference

12 December 2020

Combination of protease inhibitors for the treatment of HIV-1-infected patients: a review of pharmacokinetics and clinical experience

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

12 December 2020

Drug interaction between St John's wort and nevirapine

1 reference

12 December 2020

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

1 reference

12 December 2020

Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

1 reference

12 December 2020

Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression

1 reference

12 December 2020

Regulation of cytochrome P450 gene transcription by phenobarbital

1 reference

12 December 2020

Update: clinically significant cytochrome P-450 drug interactions

1 reference

12 December 2020

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

12 December 2020

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

12 December 2020

Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver

1 reference

12 December 2020

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

12 December 2020

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

12 December 2020

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

12 December 2020

Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital

1 reference

12 December 2020

Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity

1 reference

12 December 2020

Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

1 reference

12 December 2020

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1 reference

12 December 2020

Multidrug-resistant tuberculosis and HIV infection

1 reference

12 December 2020

Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: evidence for both genetic and environmental influences

1 reference

12 December 2020

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

1 reference

12 December 2020

Interactions between herbal medicines and prescribed drugs: a systematic review

1 reference

12 December 2020

Identification of a new class of steroid hormone receptors

1 reference

12 December 2020

Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase.

1 reference

12 December 2020

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

1 reference

12 December 2020

Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element.

1 reference

12 December 2020

10.2165/00003088-200342150-00003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674787%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

22 December 2019

1034846931

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Fatcat ID

release_6jb2yg5mkjcztjxjc7svaizrdu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6jb2yg5mkjcztjxjc7svaizrdu

24 November 2022

mapped directly with Wikidata item

1 reference