(Q34386829)

1 August 2017

1 reference

title

Role of drug metabolism in drug discovery and development (English)

1 reference

1 August 2017

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1 reference

Kumar GN

1

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PubMed ID

11579440

1 August 2017

Surapaneni S

series ordinal

2

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1 August 2017

1 September 2001

1 reference

Medicinal Research Reviews

1 August 2017

1 reference

1 August 2017

21

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1 August 2017

5

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1 August 2017

397-411

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Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

1 August 2017

1 reference

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

21 January 2018

1 reference

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

21 January 2018

1 reference

The human hepatic cytochromes P450 involved in drug metabolism

21 January 2018

1 reference

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

21 January 2018

1 reference

Metabolic activation of carcinogens

21 January 2018

1 reference

The human CYP3A subfamily: practical considerations

21 January 2018

1 reference

Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

21 January 2018

1 reference

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

1 reference

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

21 January 2018

1 reference

Substrate interaction with cytochrome P-450.

21 January 2018

1 reference

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

21 January 2018

1 reference

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

21 January 2018

1 reference

FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

21 January 2018

1 reference

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications

21 January 2018

1 reference

Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR.

21 January 2018

1 reference

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

21 January 2018

1 reference

Quantitative relationships between structure and microsomal oxidation rate of 1,4-dihydropyridines

21 January 2018

1 reference

Sulfation of minoxidil by liver sulfotransferase

21 January 2018

1 reference

Studies on the Stereoselective Metabolism of Citalopram by Human Liver Microsomes and cDNA-Expressed Cytochrome P450 Enzymes

21 January 2018

1 reference

Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents

21 January 2018

1 reference

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

21 January 2018

1 reference

Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

21 January 2018

1 reference

Inhibition and induction of cytochrome P450 and the clinical implications

21 January 2018

1 reference

Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MED.1016

1 reference

1 August 2017

1 reference

PubMed ID

11579440