(Q34346652)

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In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

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Europe PubMed Central

PubMed publication ID

1 August 2017

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

1 reference

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author name string

D J Birkett

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

D Rees

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

T Andersson

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

F J Gonzalez

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

J O Miners

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

M E Veronese

6

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Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

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publication date

1 May 1994

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

British Journal of Clinical Pharmacology

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Europe PubMed Central

PubMed publication ID

1 August 2017

37

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Europe PubMed Central

PubMed publication ID

1 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

413-420

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Family studies of mephenytoin hydroxylation deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Steady-state kinetics of proguanil and its active metabolite, cycloguanil, in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Genetic polymorphism of S-mephenytoin hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364895

6 July 2018

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1994.TB05707.X

21 January 2018

Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1994.TB05707.X

21 January 2018

Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1994.TB05707.X

21 January 2018

Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/8054246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8054246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8054246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/8054246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8054246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.1994.TB05707.X

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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