(Q39063279)

8 September 2017

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism (English)

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8 September 2017

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1 reference

1

Helsby NA

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8 September 2017

Ward SA

2

1 reference

8 September 2017

Edwards G

series ordinal

3

1 reference

8 September 2017

Howells RE

series ordinal

4

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8 September 2017

Breckenridge AM

series ordinal

5

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8 September 2017

language of work or name

English

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publication date

1 October 1990

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British Journal of Clinical Pharmacology

8 September 2017

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8 September 2017

30

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8 September 2017

4

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8 September 2017

593-598

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Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

8 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368250

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368250

Polymorphic hydroxylation of Debrisoquine in man.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368250

Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368250

A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanil

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368250

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

17 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1990.TB03818.X

Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man

21 January 2018

1 reference

12 December 2020

Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism

1 reference

12 December 2020

Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography

1 reference

12 December 2020

Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

10.1111/J.1365-2125.1990.TB03818.X

Identifiers

DOI

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8 September 2017

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8 September 2017

PubMed publication ID

2291871

1 reference