(Q33868004)

29 July 2017

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title

Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators (English)

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29 July 2017

Corton JC

1

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29 July 2017

Lapinskas PJ

series ordinal

2

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29 July 2017

Gonzalez FJ

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 March 2000

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29 July 2017

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29 July 2017

volume

448

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29 July 2017

issue

2

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29 July 2017

page(s)

139-151

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Biochemical mechanisms of induction of hepatic peroxisome proliferation

29 July 2017

cites work

1 reference

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7 January 2021

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7 January 2021

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Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

7 January 2021

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Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms

7 January 2021

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Adipogenesis and obesity: rounding out the big picture

7 January 2021

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7 January 2021

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Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo

7 January 2021

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The nuclear receptor PPARgamma - bigger than fat

7 January 2021

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The nuclear receptor superfamily: the second decade

7 January 2021

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

7 January 2021

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

7 January 2021

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

7 January 2021

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Ligand-induced peroxisome proliferator-activated receptor alpha conformational change

7 January 2021

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A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

7 January 2021

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A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs

7 January 2021

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

7 January 2021

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A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

7 January 2021

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Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor

7 January 2021

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Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

7 January 2021

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Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids

7 January 2021

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

7 January 2021

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Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens.

7 January 2021

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Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

7 January 2021

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Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver

7 January 2021

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Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor alpha is associated with Cu2+, Zn2+-superoxide dismutase in the liver

7 January 2021

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7 January 2021

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Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid

7 January 2021

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Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization

7 January 2021

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Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations

7 January 2021

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Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene

7 January 2021

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Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism

7 January 2021

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7 January 2021

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Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators

7 January 2021

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Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

7 January 2021

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Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883.

7 January 2021

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Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liver.

7 January 2021

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Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate

7 January 2021

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7 January 2021

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The absence of γglutamyl transpeptidase activity in putative preneoplastic lesions and in hepatocellular carcinomas induced in rats by the hypolipidemic peroxisome proliferator Wy-14,643

7 January 2021

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Enhancement of peroxisomal enzymes, cytochrome P-452 and DNA synthesis in putative preneoplastic foci of rat liver treated with the peroxisome proliferator nafenopin.

7 January 2021

1 reference

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Peroxisomal enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin.

7 January 2021

1 reference

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Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression.

7 January 2021

1 reference

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Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643.

7 January 2021

1 reference

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TGF alpha differentially expressed in liver foci induced by diethylnitrosamine initiation and peroxisome proliferator promotion

7 January 2021

1 reference

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Effect on the expression of c-met, c-myc and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Lack of mutations of the p53 tumor suppressor gene in hepatocellular carcinomas induced in rats by a peroxisome proliferator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase

7 January 2021

1 reference

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Expression of peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase enzyme and its mRNA in peroxisome proliferator-induced liver tumors

7 January 2021

1 reference

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Impairment of peroxisomal biogenesis in human colon carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Prostaglandin E2 and rat liver regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Kupffer cell prostaglandin-E2 production is amplified during hepatic regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Inhibitory effect of prostaglandin delta 12-PGJ2 on cell proliferation and alpha-fetoprotein expression in HuH-7 human hepatoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Hepatic peroxisome proliferation in rodents and its significance for humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

Peroxisome proliferator activated receptor-alpha expression in human liver.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900232-8

10.1016/S0027-5107(99)00232-8

7 January 2021

Identifiers

DOI

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29 July 2017

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