(Q53428750)

14 May 2018

review article

1 reference

title

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. (English)

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14 May 2018

author name string

Gonzalez FJ

series ordinal

1

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14 May 2018

Peters JM

series ordinal

2

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14 May 2018

Cattley RC

series ordinal

3

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14 May 2018

language of work or name

English

0 references

publication date

1 November 1998

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14 May 2018

Journal of the National Cancer Institute

published in

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14 May 2018

volume

90

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14 May 2018

issue

22

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14 May 2018

page(s)

1702-1709

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14 May 2018

Human carcinogens so far identified

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21 January 2018

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21 January 2018

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Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

21 January 2018

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21 January 2018

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21 January 2018

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

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PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

21 January 2018

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Adipogenesis and obesity: rounding out the big picture

21 January 2018

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

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Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

21 January 2018

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Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

21 January 2018

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Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

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Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

21 January 2018

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The PPARalpha-leukotriene B4 pathway to inflammation control.

21 January 2018

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Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

21 January 2018

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Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.

21 January 2018

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Peroxisome proliferation: current mechanisms relating to nongenotoxic carcinogenesis

21 January 2018

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Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

21 January 2018

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Use of the cytokinesis-block method for the analysis of micronuclei in V79 Chinese hamster lung cells: results with mitomycin C and cyclophosphamide

21 January 2018

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Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643.

21 January 2018

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Effect of the hepatocarcinogenic peroxisome proliferator Wy-14,643 in vivo: no increase in ethane exhalation or hepatic conjugated dienes.

21 January 2018

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Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization

21 January 2018

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Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase

21 January 2018

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Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism.

21 January 2018

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Measures of cell replication in risk/safety assessment of xenobiotic-induced, nongenotoxic carcinogenesis

21 January 2018

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Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

21 January 2018

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Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators

21 January 2018

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Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology.

21 January 2018

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Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.

21 January 2018

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Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Possible mechanisms in hepatocarcinogenesis by the peroxisome proliferator di(2-ethylhexyl)phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators

21 January 2018

1 reference

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Peroxisomal enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin.

21 January 2018

1 reference

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Role of catalase and oxidative stress in hepatic peroxisome proliferator-induced morphological transformation of Syrian hamster embryo cells

21 January 2018

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Effect on the expression of c-met, c-myc and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643.

21 January 2018

1 reference

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Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

21 January 2018

1 reference

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Discordant expression of the cyclin-dependent kinases and cyclins in rat liver following acute administration of the hepatocarcinogen [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (WY14,643).

21 January 2018

1 reference

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Time course comparison of cell-cycle protein expression following partial hepatectomy and WY14,643-induced hepatic cell proliferation in F344 rats.

21 January 2018

1 reference

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Decreased hepatocyte growth factor level by Wy-14,643, non-genotoxic hepatocarcinogen in F-344 rats.

21 January 2018

1 reference

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Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643.

21 January 2018

1 reference

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Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression.

21 January 2018

1 reference

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Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Induction of fatty acid beta-oxidation and peroxisome proliferation in the liver of rhesus monkeys by DL-040, a new hypolipidemic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Peroxisome proliferator-activated receptors: structures and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F90.22.1702

21 January 2018

Identifiers

DOI

10.1093/JNCI/90.22.1702

1 reference

14 May 2018

release_rpookich5bg2zg37ylxs6hl2pm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rpookich5bg2zg37ylxs6hl2pm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

9827524

1 reference

14 May 2018