(Q35048738)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

1 reference

title

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Alfred H Schinkel

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

language of work or name

English

0 references

publication date

1 January 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

Advanced Drug Delivery Reviews

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

55

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

3-29

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

ABC Transporters: From Microorganisms to Man

16 December 2019

cites work

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7 January 2021

A family of drug transporters: the multidrug resistance-associated proteins.

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7 January 2021

Structural, mechanistic and clinical aspects of MRP1.

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7 January 2021

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

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7 January 2021

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

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7 January 2021

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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7 January 2021

The physiological function of drug-transporting P-glycoproteins

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7 January 2021

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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7 January 2021

Role of transport proteins in drug absorption, distribution and excretion

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7 January 2021

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

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7 January 2021

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

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7 January 2021

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

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7 January 2021

Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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7 January 2021

Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors.

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7 January 2021

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

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7 January 2021

Is the multidrug transporter a flippase?

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7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Homozygous disruption of the mdrla P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Phase I and pharmacokinetic study of oral paclitaxel

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Hepatic secretion of conjugated drugs and endogenous substances

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

MRP3, an organic anion transporter able to transport anti-cancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Tissue distribution and induction of human multidrug resistant protein 3

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

A multidrug resistance transporter from human MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900169-2

7 January 2021

10.1016/S0169-409X(02)00169-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12535572%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference