(Q34005767)

English

A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Valerie Daggett

2

object named as

Valerie Daggett

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Karen Rutherford

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

1 July 2009

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

48

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

27

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

6450-6460

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Crystal structures of the apo and holo form of rat catechol-O-methyltransferase

1 reference

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5 July 2018

Dynameomics: large-scale assessment of native protein flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Crystal structures of human 108V and 108M catechol O-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease

1 reference

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5 July 2018

Current status of symptomatic medical therapy in Parkinson's disease

1 reference

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5 July 2018

Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Tolcapone improves cognition and cortical information processing in normal human subjects

1 reference

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5 July 2018

Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases

1 reference

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5 July 2018

Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Crystal structure of catechol O-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Genetics of red cell COMT activity: Analysis of thermal stability and family data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Human liver catechol-O-methyltransferase pharmacogenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Electrophoretic analysis of low and high activity forms of catechol-O-methyltransferase in human erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

5 July 2018

Effect of COMT val158met genotype on cognition and personality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

The V108M mutation decreases the structural stability of catechol O-methyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Dynameomics: mass annotation of protein dynamics and unfolding in water by high-throughput atomistic molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

The 108M polymorph of human catechol O-methyltransferase is prone to deformation at physiological temperatures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Characterization of two new variants of human catechol O-methyltransferase in vitro.

1 reference

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29 October 2018

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Cutoff size need not strongly influence molecular dynamics results for solvated polypeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Methods for molecular dynamics simulations of protein folding/unfolding in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Oxidative inhibition of human soluble catechol-O-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Thermal stability and the biochemical genetics of erythrocyte catechol-O-methyl-transferase and plasma dopamine-beta-hydroxylase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906713

29 October 2018

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase gene polymorphism and post-menopausal breast cancer risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase low activity genotype (COMTLL) is associated with low levels of COMT protein in human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase: thermolabile enzyme in erythrocytes of subjects homozygous for allele for low activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of membrane-bound catechol-O-methyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol O-methyltransferase pharmacogenetics: photoaffinity labelling and western blot analysis of human liver samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic conversion of metanephrine to epinephrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management for motor and non-motor complications in late Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19435324

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI900174V

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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