(Q34006337)

30 July 2017

title

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification (English)

1 reference

30 July 2017

5

Xander H T Wehrens

1 reference

30 July 2017

4

Randy L Johnson

1 reference

30 July 2017

Jun Wang

1

1 reference

30 July 2017

Elzbieta Klysik

series ordinal

2

1 reference

30 July 2017

Subeena Sood

series ordinal

3

1 reference

30 July 2017

James F Martin

series ordinal

6

1 reference

30 July 2017

language of work or name

English

0 references

publication date

10 May 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

1 reference

30 July 2017

volume

107

1 reference

30 July 2017

issue

21

1 reference

30 July 2017

page(s)

9753-9758

1 reference

Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Inter-relationships of atrial fibrillation and atrial flutter mechanisms and clinical implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

A genetic framework for improving arrhythmia therapy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Variants conferring risk of atrial fibrillation on chromosome 4q25.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Molecular pathway for the localized formation of the sinoatrial node

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

rVISTA 2.0: evolutionary analysis of transcription factor binding sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

KCNQ1 gain-of-function mutation in familial atrial fibrillation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Establishment of vertebrate left-right asymmetry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

New ideas about atrial fibrillation 50 years on.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Regulation of left-right asymmetry by thresholds of Pitx2c activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Function of Rieger syndrome gene in left-right asymmetry and craniofacial development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Pitx2 determines left-right asymmetry of internal organs in vertebrates.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906838

Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

MODBASE, a database of annotated comparative protein structure models, and associated resources.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912585107

Left right asymmetry, the pulmonary vein, and a-fib

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20457925

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20457925

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0912585107

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference