(Q34008891)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21886810%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis (English)

1 reference

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12 February 2020

2

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12 February 2020

author name string

Caroline Liot

1

1 reference

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12 February 2020

Aurélie Siret

3

1 reference

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12 February 2020

Catherine Crouin

4

1 reference

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12 February 2020

Susanne Schmidt

5

1 reference

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12 February 2020

Jacques Bertoglio

6

1 reference

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12 February 2020

language of work or name

English

0 references

publication date

19 August 2011

1 reference

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12 February 2020

1 reference

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12 February 2020

volume

6

1 reference

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12 February 2020

issue

8

1 reference

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12 February 2020

page(s)

e23676

1 reference

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Creative Commons Attribution 4.0 International

12 February 2020

copyright license

start time

19 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation

1 reference

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Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis

5 July 2018

1 reference

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The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

5 July 2018

1 reference

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UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat

5 July 2018

1 reference

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p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells.

5 July 2018

1 reference

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Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.

5 July 2018

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Regulation of cytokinesis by Rho GTPase flux

5 July 2018

1 reference

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The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

5 July 2018

1 reference

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A quantitative atlas of mitotic phosphorylation

5 July 2018

1 reference

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Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

5 July 2018

1 reference

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Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.

5 July 2018

1 reference

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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

The anaphase promoting complex/cyclosome: a machine designed to destroy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Dissecting the role of Rho-mediated signaling in contractile ring formation

5 July 2018

1 reference

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Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes.

5 July 2018

1 reference

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Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Cell type-specific regulation of RhoA activity during cytokinesis.

5 July 2018

1 reference

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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

5 July 2018

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Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2

5 July 2018

1 reference

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Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

5 July 2018

1 reference

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Rho GTPases in cell biology

5 July 2018

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5 July 2018

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5 July 2018

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Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Oncogene ect2 is related to regulators of small GTP-binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

Cyclin is degraded by the ubiquitin pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Cell cycle regulation of central spindle assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

10.1371/JOURNAL.PONE.0023676

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21886810%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21886810%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

21886810

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21886810%20AND%20SRC:MED&resulttype=core&format=json