(Q34016369)

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Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11867721%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia (English)

1 reference

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7 December 2019

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Richard A. Larson

7

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7 December 2019

Michelle M Le Beau

6

object named as

Michelle M Le Beau

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7 December 2019

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Janet D Rowley

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7 December 2019

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Yanming Zhang

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7 December 2019

Pamela Strissel

2

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7 December 2019

Reiner Strick

3

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7 December 2019

Jianjun Chen

4

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7 December 2019

Giuseppina Nucifora

5

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7 December 2019

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publication date

26 February 2002

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7 December 2019

Proceedings of the National Academy of Sciences of the United States of America

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7 December 2019

99

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7 December 2019

3070-3075

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7 December 2019

5

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7 December 2019

Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals

1 reference

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5 July 2018

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

The role of chromosome translocations in leukemogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Functional analysis of DNA sequences located within a cluster of DNase I hypersensitive sites colocalizing with a MAR element at the upstream border of the chicken alpha-globin gene domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Establishment and characterization of a megakaryoblast cell line with amplification of MLL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Scaffold-associated regions in the human type I interferon gene cluster on the short arm of chromosome 9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Extension of chromatin accessibility by nuclear matrix attachment regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Chromatin domains and prediction of MAR sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Structure and function of type II DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

DNA topoisomerase poisons as antitumor drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Chromosome assembly in vitro: Topoisomerase II is required for condensation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Chromatin structure, not DNA sequence specificity, is the primary determinant of topoisomerase II sites of action in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Human telomeres are attached to the nuclear matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

5 July 2018

SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

29 October 2018

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122474

29 October 2018

t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Chromatin domain surrounding the human interferon-beta gene as defined by scaffold-attached regions

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Scaffold attachment regions in centromere-associated DNA

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Molecular characterization of the genomic breakpoints in a case of t(3;21)(q26;q22)

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.042702899

21 January 2018

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/11867721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11867721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region

1 reference

https://pubmed.ncbi.nlm.nih.gov/11867721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11867721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11867721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.042702899

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11867721%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

2002PNAS...99.3070Z

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11867721%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11867721%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

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