(Q34018746)

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Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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Europe PubMed Central

Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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Giles See How Yeo

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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Ashwini Oswal

1

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Europe PubMed Central

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4 February 2020

publication date

30 July 2009

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

18

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

2

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Europe PubMed Central

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4 February 2020

221-229

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19644451%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin and OB-R: body weight regulation by a cytokine receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Role of leptin in the neuroendocrine response to fasting

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The hormonal control of food intake

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

SnapShot: the hormonal control of food intake.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Identification and expression cloning of a leptin receptor, OB-R

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Divergent signaling capacities of the long and short isoforms of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Distributions of leptin receptor mRNA isoforms in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Mechanisms of leptin action and leptin resistance

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin resistance: a prediposing factor for diet-induced obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Blood-brain barrier and energy balance

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The blood-brain barrier as a cause of obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Triglycerides induce leptin resistance at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Activation of downstream signals by the long form of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Intracellular signalling. Key enzyme in leptin-induced anorexia

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Intracellular mechanisms involved in leptin regulation of sympathetic outflow

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

A family of cytokine-inducible inhibitors of signalling

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The role of SOCS-3 in leptin signaling and leptin resistance

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Critical role of STAT3 in leptin's metabolic actions

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

PTP1B regulates leptin signal transduction in vivo

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Neuronal PTP1B regulates body weight, adiposity and leptin action.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Rapid rewiring of arcuate nucleus feeding circuits by leptin.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Trophic action of leptin on hypothalamic neurons that regulate feeding

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin and its role in hippocampal synaptic plasticity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin reverses long-term potentiation at hippocampal CA1 synapses

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Modulation of food reward by adiposity signals

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin regulation of the mesoaccumbens dopamine pathway.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Modulation of brain reward circuitry by leptin.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin receptor signaling in midbrain dopamine neurons regulates feeding

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Lateral hypothalamic neuropeptides in reward and drug addiction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

A role for lateral hypothalamic orexin neurons in reward seeking

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Food restriction and leptin impact brain reward circuitry in lean and obese Zucker rats.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Leptin regulates striatal regions and human eating behavior

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Ghrelin modulates brain activity in areas that control appetitive behavior

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Effects of gender, body composition, and menopause on plasma concentrations of leptin

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

21 January 2018

Atypical antipsychotics and glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

31 March 2020

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

7 January 2021

based on heuristic

inferred from DOI database lookup

The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2009.228

7 January 2021

based on heuristic

inferred from DOI database lookup

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