(Q34027499)

30 July 2017

title

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness (English)

1 reference

30 July 2017

Sean J Morrison

8

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author name string

Qing Li

1

1 reference

30 July 2017

Natacha Bohin

2

1 reference

30 July 2017

Tiffany Wen

3

1 reference

30 July 2017

Victor Ng

4

1 reference

30 July 2017

Jeffrey Magee

5

1 reference

30 July 2017

Shann-Ching Chen

6

1 reference

30 July 2017

Kevin Shannon

7

1 reference

30 July 2017

language of work or name

English

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publication date

27 November 2013

1 reference

30 July 2017

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30 July 2017

volume

504

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30 July 2017

issue

7478

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30 July 2017

page(s)

143-147

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SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Dnmt3a is essential for hematopoietic stem cell differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Oncogenic Kras initiates leukemia in hematopoietic stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Stems cells and the pathways to aging and cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Bioconductor: open software development for computational biology and bioinformatics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

SOCS proteins: negative regulators of cytokine signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Quantitative effects of Nf1 inactivation on in vivo hematopoiesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128640

Targeting oncogenic Ras signaling in hematologic malignancies

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

IFNalpha activates dormant haematopoietic stem cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Clonal architecture of chronic myelomonocytic leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Germ-line mutation of the NRAS gene may be responsible for the development of juvenile myelomonocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Constitutional NRAS mutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12830

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24284627

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE12830

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference