(Q34029480)

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Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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Jason M Haugh

2

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author name string

Murat Cirit

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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publication date

1 January 2012

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Europe PubMed Central

PubMed publication ID

30 July 2017

Biochemical Journal

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Europe PubMed Central

PubMed publication ID

30 July 2017

441

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Europe PubMed Central

PubMed publication ID

30 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

77-85

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Cell signaling by receptor tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Role of RAS in the regulation of PI 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

1 reference

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Cancer systems biology: a network modeling perspective

1 reference

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Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

1 reference

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5 July 2018

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

1 reference

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Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk

1 reference

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Universally sloppy parameter sensitivities in systems biology models

1 reference

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Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks

1 reference

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

1 reference

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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

1 reference

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A theoretical framework for specificity in cell signaling

1 reference

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A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

1 reference

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H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Single-molecule imaging analysis of Ras activation in living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Ras pathway signaling on endomembranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

1 reference

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5 July 2018

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

1 reference

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

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5 July 2018

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

1 reference

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5 July 2018

Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687362

5 July 2018

Protein molecules as computational elements in living cells

1 reference

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5 July 2018

Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors

1 reference

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Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase

1 reference

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Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells

1 reference

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Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110833

21 January 2018

Why we need quantitative dynamic models.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110833

21 January 2018

Subcellular localization determines MAP kinase signal output.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110833

21 January 2018

Tandem SH2 domains confer high specificity in tyrosine kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21943356

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21943356

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A global analysis of cross-talk in a mammalian cellular signalling network

1 reference

https://pubmed.ncbi.nlm.nih.gov/21943356

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20110833

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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