(Q34029869)

30 July 2017

title

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo (English)

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chronic lymphocytic leukemia

30 July 2017

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ChEBI release 2020-05-28

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6

William G Wierda

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30 July 2017

8

Susan O'Brien

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30 July 2017

7

Michael J Keating

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30 July 2017

10

Jan A Burger

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30 July 2017

4

Kumudha Balakrishnan

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30 July 2017

9

Nicholas Chiorazzi

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30 July 2017

Sabine Ponader

1

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30 July 2017

Shih-Shih Chen

series ordinal

2

1 reference

30 July 2017

Joseph J Buggy

series ordinal

3

1 reference

30 July 2017

Varsha Gandhi

series ordinal

5

1 reference

30 July 2017

language of work or name

English

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publication date

16 December 2011

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30 July 2017

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30 July 2017

volume

119

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30 July 2017

issue

5

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30 July 2017

page(s)

1182-1189

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

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5 July 2018

1 reference

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The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

5 July 2018

1 reference

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The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

5 July 2018

1 reference

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

5 July 2018

1 reference

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

5 July 2018

1 reference

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The microenvironment in mature B-cell malignancies: a target for new treatment strategies

5 July 2018

1 reference

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B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

5 July 2018

1 reference

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5 July 2018

1 reference

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High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

5 July 2018

1 reference

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Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

5 July 2018

1 reference

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Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

5 July 2018

1 reference

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5 July 2018

1 reference

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In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

5 July 2018

1 reference

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

5 July 2018

1 reference

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Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee.

5 July 2018

1 reference

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Chronic lymphocytic leukemia: revelations from the B-cell receptor.

5 July 2018

1 reference

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B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor

5 July 2018

1 reference

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

5 July 2018

1 reference

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

5 July 2018

1 reference

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The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms

5 July 2018

1 reference

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Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

5 July 2018

1 reference

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Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

5 July 2018

1 reference

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Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

29 October 2018

1 reference

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Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events

29 October 2018

1 reference

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Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Expression of Bruton's tyrosine kinase protein within the B cell lineage

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916557

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22180443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-10-386417

1 reference

30 July 2017

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30 July 2017

1 reference