(Q34030237)

30 July 2017

title

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds (English)

1 reference

30 July 2017

8

Roger G Linington

1 reference

30 July 2017

Tina R White

1

1 reference

30 July 2017

Chad M Renzelman

2

1 reference

30 July 2017

Arthur C Rand

3

1 reference

30 July 2017

Taha Rezai

4

1 reference

30 July 2017

Cayla M McEwen

5

1 reference

30 July 2017

Vladimir M Gelev

6

1 reference

30 July 2017

Rushia A Turner

7

1 reference

30 July 2017

Siegfried S F Leung

9

1 reference

30 July 2017

Amit S Kalgutkar

10

1 reference

30 July 2017

Jonathan N Bauman

11

1 reference

30 July 2017

Yizhong Zhang

12

1 reference

30 July 2017

Spiros Liras

13

1 reference

30 July 2017

David A Price

14

1 reference

30 July 2017

Alan M Mathiowetz

15

1 reference

30 July 2017

Matthew P Jacobson

16

1 reference

30 July 2017

R Scott Lokey

17

1 reference

30 July 2017

publication date

25 September 2011

1 reference

30 July 2017

published in

Nature Chemical Biology

1 reference

30 July 2017

volume

7

1 reference

30 July 2017

issue

11

1 reference

30 July 2017

page(s)

810-817

1 reference

The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

N-methylation of peptides: a new perspective in medicinal chemistry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

The exploration of macrocycles for drug discovery--an underexploited structural class

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

A hierarchical approach to all-atom protein loop prediction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

The cyclization of peptides and depsipeptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

Libraries from libraries: generation and comparison of screening profiles.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

Crystal and molecular structure of Destruxin B

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Effect of peptide conformation on membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Effect of serum lipids on the pharmacokinetics of atazanavir in hyperlipidemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Long-term levothyroxine treatment decreases the oral bioavailability of cyclosporin A by inducing P-glycoprotein in small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Long-term pharmacokinetic efficacy and safety of low-dose ritonavir as a booster and atazanavir pharmaceutical formulation based on solid dispersion system in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Permeation prediction of M100240 using the parallel artificial membrane permeability assay.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210067

A potent cyclic hexapeptide analogue of somatostatin

29 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.664

Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides

21 January 2018

1 reference

12 December 2020

The effect of beta-turn structure on the passive diffusion of peptides across Caco-2 cell monolayers

1 reference

12 December 2020

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

12 December 2020

Unique molecular conformation of aureobasidin A, a highly amide N-methylated cyclic depsipeptide with potent antifungal activity: X-ray crystal structure and molecular modeling studies

1 reference

12 December 2020

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

1 reference

12 December 2020

Deuterium exchange as an indicator of hydrogen bond donors and acceptors

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.664

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference