(Q34037595)

English

A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

0 references

single-nucleotide polymorphism

1 reference

based on heuristic

inferred from title

heroin dependence

1 reference

based on heuristic

inferred from title

Gavril W. Pasternak

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

11

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

9

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Yasmin L Hurd

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Jin Xu

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Zhigang Lu

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mingming Xu

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ling Pan

4

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Yi Deng

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Xiaohu Xie

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Huifen Liu

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Shixiong Ding

8

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Luca Cartegni

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ying-Xian Pan

14

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

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publication date

1 August 2014

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Europe PubMed Central

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30 July 2017

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

34

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

33

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

11048-11066

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mu opioids and their receptors: evolution of a concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Functional characterization of human variants of the mu-opioid receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

A new positive/negative selection scheme for precise BAC recombineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

The mu-opioid receptor gene and smoking initiation and nicotine dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Genomic variations and transcriptional regulation of the human mu-opioid receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Pharmacotherapy and pharmacogenetics of nicotine dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

How individual sensitivity to opiates can be predicted by gene analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – Excel-based tool using pair-wise correlations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

ASD: the Alternative Splicing Database.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

ESEfinder: A web resource to identify exonic splicing enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Probability-based protein identification by searching sequence databases using mass spectrometry data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Characterization of an intron splice enhancer that regulates alternative splicing of human GH pre-mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Intron definition is required for excision of the minute virus of mice small intron and definition of the upstream exon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken beta-tropomyosin pre-mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

G+C-rich tract in 5' end of human introns.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

5 July 2018

Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Association of functional opioid receptor genotypes with alcohol dependence in Koreans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Functional analysis of MOR‐1 splice variants of the mouse mu opioid receptor gene Oprm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131016

29 October 2018

Identifiers

10.1523/JNEUROSCI.3986-13.2014

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25122903%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

ResearchGate publication ID

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