(Q34039761)

30 July 2017

title

Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity (English)

1 reference

30 July 2017

Michelle L Wynn

1

1 reference

30 July 2017

Alejandra C Ventura

2

1 reference

30 July 2017

Jacques A Sepulchre

3

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30 July 2017

Héctor J García

4

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30 July 2017

Sofia D Merajver

5

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30 July 2017

publication date

4 October 2011

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30 July 2017

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30 July 2017

volume

5

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30 July 2017

page(s)

156

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Long signaling cascades tend to attenuate retroactivity

30 July 2017

cites work

1 reference

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Substrate-dependent control of MAPK phosphorylation in vivo

5 July 2018

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Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.

5 July 2018

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BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

5 July 2018

1 reference

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Signaling properties of a covalent modification cycle are altered by a downstream target

5 July 2018

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Signal integration by JNK and p38 MAPK pathways in cancer development

5 July 2018

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5 July 2018

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Robust, tunable biological oscillations from interlinked positive and negative feedback loops.

5 July 2018

1 reference

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A methodology for performing global uncertainty and sensitivity analysis in systems biology.

5 July 2018

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A hidden feedback in signaling cascades is revealed

5 July 2018

1 reference

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Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells

5 July 2018

1 reference

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Modular cell biology: retroactivity and insulation

5 July 2018

1 reference

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

5 July 2018

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5 July 2018

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Dynamics of the p53-Mdm2 feedback loop in individual cells

5 July 2018

1 reference

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Ultrasensitivity in the mitogen-activated protein kinase cascade

5 July 2018

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5 July 2018

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An amplified sensitivity arising from covalent modification in biological systems

5 July 2018

1 reference

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Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1752-0509-5-156

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1752-0509-5-156

How robust are switches in intracellular signaling cascades?

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1752-0509-5-156

21 January 2018

Identifiers

DOI

10.1186/1752-0509-5-156

1 reference

journals/bmcsb/WynnVSGM11

30 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

0 references

1 reference

30 July 2017

1 reference