(Q34047854)

30 July 2017

title

The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei (English)

1 reference

cAMP-specific phosphodiesterase

30 July 2017

0 references

1 reference

GeneDB

cAMP-specific phosphodiesterase

6 February 2019

1 reference

GeneDB

cAMP-specific phosphodiesterase, putative

6 February 2019

0 references

cAMP-specific phosphodiesterase, putative

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cAMP-specific phosphodiesterase, putative

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author name string

Roya Zoraghi

series ordinal

1

1 reference

30 July 2017

Thomas Seebeck

series ordinal

2

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 April 2002

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

1 reference

30 July 2017

volume

99

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30 July 2017

issue

7

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30 July 2017

page(s)

4343-4348

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Potential novel therapies for chronic obstructive pulmonary disease.

30 July 2017

cites work

1 reference

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New drugs for the treatment of human African trypanosomiasis: research and development

5 July 2018

1 reference

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Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication

5 July 2018

1 reference

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Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy

5 July 2018

1 reference

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Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor

5 July 2018

1 reference

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Cyclic nucleotide phosphodiesterases: relating structure and function

5 July 2018

1 reference

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Modifications of retinal neurons in a mouse model of retinitis pigmentosa

5 July 2018

1 reference

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The cAMP signaling pathway as a therapeutic target in lymphoid malignancies.

5 July 2018

1 reference

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Therapeutic potential of phosphodiesterase-4 and -3 inhibitors in Th1-mediated autoimmune diseases

5 July 2018

1 reference

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Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD).

5 July 2018

1 reference

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Sildenafil: a review of its use in erectile dysfunction

5 July 2018

1 reference

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A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling

5 July 2018

1 reference

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The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

A high-throughput assay for cyclic nucleotide phosphodiesterases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Oxpentifylline inhibits tumor necrosis factor‐α mRNA transcription and protects against arthritis in mercuric chloride‐treated Brown Norway rats

5 July 2018

1 reference

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Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

5 July 2018

1 reference

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The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Single odors differentially stimulate dual second messenger pathways in lobster olfactory receptor cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123650

Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit

28 October 2018

1 reference

12 December 2020

cGMP phosphodiesterase-alpha mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dog

1 reference

12 December 2020

Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters

1 reference

12 December 2020

Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.062716599

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference