(Q34052405)

30 July 2017

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title

Proteasome inhibitors: from in vitro uses to clinical trials (English)

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30 July 2017

Rivett AJ

1

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30 July 2017

Gardner RC

series ordinal

2

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30 July 2017

publication date

1 September 2000

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Journal of Peptide Science

30 July 2017

published in

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30 July 2017

volume

6

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30 July 2017

issue

9

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30 July 2017

page(s)

478-488

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Structure and functions of the 20S and 26S proteasomes

30 July 2017

cites work

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The proteasome: paradigm of a self-compartmentalizing protease

21 January 2018

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The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

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ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

21 January 2018

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Degradation of cell proteins and the generation of MHC class I-presented peptides

21 January 2018

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The multicatalytic proteinase of mammalian cells

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Roles of ubiquitin-mediated proteolysis in cell cycle control

21 January 2018

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Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

21 January 2018

1 reference

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

21 January 2018

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A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

21 January 2018

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The structures of HsIU and the ATP-dependent protease HsIU-HsIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Proteasome from Thermoplasma acidophilum: a threonine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Identical subunit topographies of human and yeast 20S proteasomes

21 January 2018

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https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Processing of N3, a mammalian proteasome beta-type subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Cation-sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The multicatalytic proteinase complex (proteasome): structure and conformational changes associated with changes in proteolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The proteasome, a novel protease regulated by multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Bivalency as a principle for proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

A giant protease with potential to substitute for some functions of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The role of the ubiquitin-proteasome pathway in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Epoxomicin, a new antitumor agent of microbial origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Proteasome inhibition: A novel mechanism to combat asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

A proteolytic system that compensates for loss of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

A novel chymotrypsin-like component of the multicatalytic proteinase complex optimally active at acidic pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Proteasome β-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Use of serine-protease inhibitors as probes for the different proteolytic activities of the rat liver multicatalytic proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Multicatalytic endopeptidase complex: proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Active site-directed inhibitors of Rhodococcus 20 S proteasome. Kinetics and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Catalytic Properties of 26 S and 20 S Proteasomes and Radiolabeling of MB1, LMP7, and C7 Subunits Associated with Trypsin-like and Chymotrypsin-like Activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1099-1387%28200009%296%3A9%3C478%3A%3AAID-PSC285%3E3.0.CO%3B2-F

10.1002/1099-1387(200009)6:9<478::AID-PSC285>3.0.CO;2-F

21 January 2018

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DOI

1 reference

30 July 2017

1 reference