(Q34052884)

30 July 2017

Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1A (English)

1 reference

30 July 2017

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Rashmi Kothary

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Xandra O. Breakefield

13

object named as

Xandra O Breakefield

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Jasmin Hettich

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Osmar Norberto de Souza

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Luís Fernando Saraiva Macedo Timmers

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Shelun Tsai

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Nadia A Atai

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Cintia C da Hora

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Xuan Zhang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Maria Ericsson

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Kathrin Grundmann

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Flávia C Nery

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Erik Snapp

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

17 July 2014

1 reference

30 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

1101-1113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

8 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

All-atom empirical potential for molecular modeling and dynamics studies of proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Arresting a Torsin ATPase reshapes the endoplasmic reticulum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Subtle microstructural changes of the cerebellum in a knock-in mouse model of DYT1 dystonia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Structural basis for cooperativity of CRM1 export complex formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Nesprin-3: a versatile connector between the nucleus and the cytoskeleton

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

TorsinA participates in endoplasmic reticulum-associated degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Superfolder GFP is fluorescent in oxidizing environments when targeted via the Sec translocon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

MolProbity: all-atom structure validation for macromolecular crystallography

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Safety and efficacy of gene transfer for Leber's congenital amaurosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystonia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Statistical potential for assessment and prediction of protein structures

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Engineering and characterization of a superfolder green fluorescent protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

AAA+ proteins: have engine, will work

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Optimized large-scale production of high titer lentivirus vector pseudotypes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

TorsinA in the nuclear envelope

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

TorsinA: movement at many levels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

AAA+ superfamily ATPases: common structure--diverse function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Evaluation of methods for the prediction of membrane spanning regions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Multicolour imaging of post-Golgi sorting and trafficking in live cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

AAA proteins. Lords of the ring

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Comparative protein modelling by satisfaction of spatial restraints

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Concept and classification of dystonia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Idiopathic dystonia among Ashkenazi Jews: evidence for autosomal dominant inheritance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

A highly sensitive assay for monitoring the secretory pathway and ER stress

28 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Consequences of the DYT1 mutation on torsinA oligomerization and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Evolutionary history and higher order classification of AAA+ ATPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Mutations in DYT1: extension of the phenotypic and mutational spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Susceptibility to DYT1 dystonia in European patients is modified by the D216H polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Effects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus I. Analysis of neutralizing epitopes with monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

A functional role for TorsinA in herpes simplex virus 1 nuclear egress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

A tightly regulated molecular toggle controls AAA+ disaggregase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

SignalP 4.0: discriminating signal peptides from transmembrane regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Novel chromophores and buried charges control color in mFruits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Regulation of Torsin ATPases by LAP1 and LULL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

The torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to Sensor-II that couples redox state to nucleotide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Novel TOR1A mutation p.Arg288Gln in early-onset dystonia (DYT1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134760

Myoclonus-dystonia: clinical and genetic evaluation of a large cohort

28 October 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex: a molecular dynamics simulation study

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24930953

12 December 2020

inferred from PubMed ID database lookup

Molecular dynamics simulations of a protein-protein dimer: particle-mesh Ewald electrostatic model yields far superior results to standard cutoff model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24930953

12 December 2020

inferred from PubMed ID database lookup

Clinical findings of a myoclonus-dystonia family with two distinct mutations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24930953

12 December 2020

inferred from PubMed ID database lookup

Tolcapone: COMT inhibition for the treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22602

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/HUMU.22602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930953%20AND%20SRC:MED&resulttype=core&format=json