(Q34061168)

30 July 2017

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title

Rationale and applications of lipids as prodrug carriers (English)

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30 July 2017

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Lambert DM

1

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30 July 2017

language of work or name

English

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publication date

1 October 2000

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European Journal of Pharmaceutical Sciences

30 July 2017

published in

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30 July 2017

volume

11 Suppl 2

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30 July 2017

page(s)

S15-27

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Chemical Aspects of Selective Toxicity

30 July 2017

cites work

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7 January 2021

Pancreatic lipase-catalyzed hydrolysis of esters of hydroxymethyl phenytoin dissolved in various metabolizable vehicles, dispersed in micellar systems, and in aqueous suspensions

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7 January 2021

Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles

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7 January 2021

Physicochemical characterization of a synthetic lipid emulsion for hepatocyte-selective delivery of lipophilic compounds: application to polyiodinated triglycerides as contrast agents for computed tomography

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7 January 2021

Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo

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7 January 2021

Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Molecular cloning of a human gastric lipase and expression of the enzyme in yeast

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Kinetics of (16 123I) iodohexadecenoic acid metabolism in the rat myocardium, influence of glucose concentration in the perfusate and comparison with (1 14C) palmitate

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7 January 2021

Gastric lipase: crystal structure and activity

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7 January 2021

Structural basis for the substrate selectivity of pancreatic lipases and some related proteins

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7 January 2021

Pharmacological studies in the rat with [2-(1,3-didecanoyloxy)-propyl]2-acetyloxybenzoate (A-45474): an aspirin pro-drug with negligible gastric irritation

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Novel anti-inflammatory agents

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis and in vitro study of a diglyceride prodrug of a peptide

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

In-vitro evaluation of filaricidal activity of GABA and 1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol HCl: a diglyceride prodrug

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Incorporation of xenobiotic carboxylic acids into lipids

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Xenobiotic lipids: the inclusion of xenobiotic compounds in pathways of lipid biosynthesis

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Lipophilic xenobiotic conjugates: the pharmacological and toxicological consequences of the participation of drugs and other foreign compounds as substrates in lipid biosynthesis

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Evaluation of nonionic nitroxyl lipids as potential organ-specific contrast agents for magnetic resonance imaging

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7 January 2021

Evaluation of a nitroxyl fatty acid as liver contrast agent for magnetic resonance imaging

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

1,3-dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agent

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

A lymphotropic prodrug of L-dopa: synthesis, pharmacological properties, and pharmacokinetic behavior of 1,3-dihexadecanoyl-2-[(S)-2-amino-3-(3,4-dihydroxyphenyl)prop anoyl] propane-1,2,3-triol

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

The metabolism of the xenobiotic triacylglycerols, rac-1- and sn-2- (3-phenoxybenzoyl)-dipalmitoylglycerol, following intravenous administration to the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

The metabolism of 3-phenoxybenzoic acid-containing xenobiotic triacylglycerols in vitro by pancreatic, hormone-sensitive and lipoprotein lipases

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

1-beta-D-arabinofuranosylcytosine-phospholipid conjugates as prodrugs of Ara-C

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Nucleoside conjugates. 10. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

gamma-Aminobutyric acid esters. 2. Synthesis, brain uptake, and pharmacological properties of lipid esters of gamma-aminobutyric acid

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

gamma-Aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturation

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor gamma-vinyl-GABA.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Serum concentrations of cis(Z)-flupentixol and prolactin in chronic schizophrenic patients treated with flupentixol and cis(Z)-flupentixol decanoate

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

The intramyocardial fate of [1-14C] palmitate, iodopalmitate and iodophenylpentadecanoate in isolated rat hearts. A contribution to the choice of an iodinated fatty acid as a tracer of myocardial metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Gastric ulceration and the concentration of salicylate in plasma in rats after administration of 14C-labelled aspirin and its synthetic triglyceride, 1,3-dipalmitoyl-2(2′-acetoxy-[14C]carboxylbenzoyl) glycerol

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Drug-phospholipid conjugates as potential prodrugs: synthesis, characterization, and degradation by pancreatic phospholipase A(2).

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Analgesic potency of S-acetylthiorphan after intravenous administration to mice

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

1,3-Diacylaminopropan-2-ols and corresponding 2-acyl derivatives as drug carriers: unexpected pharmacological properties

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3- diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Lymphotropic antifilarial agents derived from closantel and chlorambucil.

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Study of lymphotropic targeting and macrofilaricidal activity of a melphalan prodrug on the Molinema dessetae model

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Formulation of polyiodinated triglyceride analogues in a chylomicron remnant-like liver-selective delivery vehicle

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Phase behaviour of a diglyceride prodrug: spontaneous formation of unilamellar vesicles

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis of 1,3-diacylaminopropan-2-ols and corresponding 2-acyl derivatives as amide isosteres of natural lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Xenobiotic triacylglycerol formation in isolated hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Glycerides as prodrugs. 1. Synthesis and antiinflammatory activity of 1,3-bis(alkanoyl)-2-(O-acetylsalicyloyl)glycerides (aspirin triglycerides)

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Glycerides as prodrugs. 2. 1,3-Dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides (cyclic aspirin triglycerides) as antiinflammatory agents

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides)

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

123I-phenylpentadecanoic acid as a tracer of cardiac free fatty acid metabolism. Experimental and clinical results

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Deacylation-reacylation cycle: a possible absorption mechanism for the novel lymphotropic antitumor agent dipalmitoylphosphatidylfluorouridine in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Potential organ or tumor imaging agents. 32. A triglyceride ester of p-iodophenyl pentadecanoic acid as a potential hepatic imaging agent

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Phenytoin-lipid conjugates as potential prodrugs of phenytoin

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Phenytoin-lipid conjugates: chemical, plasma esterase-mediated, and pancreatic lipase-mediated hydrolysis in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis and in vitro evaluation of 4-(2-glyceryl)butyric acid: a glyceride mimic for drug delivery via drug-lipid conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Anticonvulsant Activity of Phenytoin-lipid Conjugates, a New Class of Phenytoin Prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Bioavailability and anticonvulsant activity of a monoglyceride-derived prodrug of phenytoin after oral administration to rats

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Bioavailability of phenytoin following oral administration of phenytoin-lipid conjugates to rats

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Bioavailability of phenytoin and anticonvulsant activity after oral administration of phenytoin-bis-hydroxyisobutyrate to rats

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Studies on intestinal lymphatic absorption of drugs. II. Glyceride prodrugs for improving lymphatic absorption of naproxen and nicotinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Lymphatic absorption of hypolipidemic compound, 1-O-[p-(myristyloxy)-alpha-methylcinnamoyl] glycerol (LK-903)

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Radionuclide assessment of myocardial fatty acid metabolism by PET and SPECT.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Prodrugs revisited: the "ad hoc" approach as a complement to ligand design

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Phosphoglyceride metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Colipase: structure and interaction with pancreatic lipase

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Synthesis and antiviral activity of 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Potential tumor- or organ-imaging agents. 26. Polyiodinated 2-substituted triacylglycerols as hepatographic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Potential tumor- or organ-imaging agents. 27. Polyiodinated 1,3-disubstituted and 1,2,3-trisubstituted triacylglycerols

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

Computed tomography scanning of hepatic tumors with polyiodinated triglycerides

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900161-5

7 January 2021

10.1016/S0928-0987(00)00161-5

Identifiers

DOI

1 reference

30 July 2017

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