(Q34065084)

English

Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant (English)

1 reference

Europe PubMed Central

30 July 2017

3

object named as

Arne Holmgren

1 reference

Europe PubMed Central

30 July 2017

author name string

Rong Zhao

1

1 reference

Europe PubMed Central

30 July 2017

Hiroyuki Masayasu

2

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

17 June 2002

1 reference

Europe PubMed Central

30 July 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

30 July 2017

99

1 reference

Europe PubMed Central

30 July 2017

13

1 reference

Europe PubMed Central

30 July 2017

8579-8584

1 reference

Europe PubMed Central

30 July 2017

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Physiological functions of thioredoxin and thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Redox signaling: hydrogen peroxide as intracellular messenger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Selenium and the thioredoxin redox system: effects on cell growth and death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Selenium and the thioredoxin and glutaredoxin systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Cloning and expression of a novel mammalian thioredoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Molecular actions of Ebselen—an antiinflammatory antioxidant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Thioredoxin and glutaredoxin systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Axoplasmic transport of thioredoxin and thioredoxin reductase in rat sciatic nerve.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

5 July 2018

Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Localization of thioredoxin in the rat brain and functional implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124318

28 October 2018

Rat liver thioredoxin and thioredoxin reductase: purification and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel biologically active seleno-organic compound—1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel biologically active selenooorganic compound--VII. Biotransformation of ebselen in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ebselen-binding equilibria between plasma and target proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and assay of mammalian thioredoxin and thioredoxin reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12070343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.122061399

1 reference

Europe PubMed Central

30 July 2017

2002PNAS...99.8579Z

0 references

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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0 references

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