(Q34069613)

30 July 2017

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title

The endothelin system in septic and endotoxin shock (English)

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ORCID Public Data File 2021

30 July 2017

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author name string

Wanecek M

1

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30 July 2017

Weitzberg E

2

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30 July 2017

Rudehill A

3

1 reference

30 July 2017

Oldner A

4

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30 July 2017

language of work or name

English

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publication date

1 October 2000

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European Journal of Pharmacology

30 July 2017

published in

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30 July 2017

volume

407

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30 July 2017

issue

1-2

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30 July 2017

page(s)

1-15

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The role of endothelin in radiocontrast nephropathy

30 July 2017

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ

7 January 2021

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Reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes

7 January 2021

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7 January 2021

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Endothelin, vasoconstriction, and endothelial damage in Raynaud's phenomenon

7 January 2021

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7 January 2021

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Physiologic and pathophysiologic roles of endothelin in the kidney.

7 January 2021

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BQ-123, a peptidic endothelin ETA receptor antagonist, prevents the early cerebral vasospasm following subarachnoid hemorrhage after intracisternal but not intravenous injection.

7 January 2021

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Reactivity of endothelin-1 on human and canine large veins compared with large arteries in vitro

7 January 2021

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Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure

7 January 2021

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Endothelin-1-induced contraction of pulmonary arteries from endotoxemic rats is attenuated by the endothelin-A receptor antagonist, BQ123

7 January 2021

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Endothelin ETA and ETB mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ETA sub-type

7 January 2021

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Endothelin-mediated positive inotropic effect induced by reactive oxygen species in isolated cardiac muscle

7 January 2021

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Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor

7 January 2021

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Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock

7 January 2021

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Endothelin-1 in adult respiratory distress syndrome

7 January 2021

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Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors

7 January 2021

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Endothelins, peptides with potent vasoactive properties, are produced by human macrophages

7 January 2021

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Molecular characterization of a novel human endothelin receptor splice variant

7 January 2021

1 reference

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Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells

7 January 2021

1 reference

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Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

7 January 2021

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Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines

7 January 2021

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Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors

7 January 2021

1 reference

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Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors

7 January 2021

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Cytopathic hypoxia in sepsis

7 January 2021

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Synergistic inhibition by BQ-123 and BQ-788 of endothelin-1-induced contractions of the rabbit pulmonary artery

7 January 2021

1 reference

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Enhancement of the hypotensive and vasodilator effects of endotoxaemia in conscious rats by the endothelin antagonist, SB 209670.

7 January 2021

1 reference

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Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia

7 January 2021

1 reference

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Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung.

7 January 2021

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Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

7 January 2021

1 reference

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The distribution and density of receptor subtypes for endothelin-1 in peripheral lung of the rat, guinea-pig and pig.

7 January 2021

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The endothelins in the pulmonary system

7 January 2021

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The endothelin A receptor antagonist LU 135252 protects the myocardium from neutrophil injury during ischaemia/reperfusion

7 January 2021

1 reference

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Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits

7 January 2021

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An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.

7 January 2021

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Endothelin production in cultured vascular smooth muscle cells--modulation by the atrial, brain, and C-type natriuretic peptide system.

7 January 2021

1 reference

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Contribution of endogenous generation of endothelin-1 to basal vascular tone

7 January 2021

1 reference

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An orally active non-selective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis

7 January 2021

1 reference

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The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin

7 January 2021

1 reference

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Potential pathophysiologic role of endothelin-1 in canine pericardial fluid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Microcirculatory oxygenation and shunting in sepsis and shock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin-1 as an aggravating factor of disseminated intravascular coagulation associated with malignant neoplasms

7 January 2021

1 reference

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Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

7 January 2021

1 reference

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Endothelin-1 enhances vascular cell adhesion molecule-1 expression in tumor necrosis factor alpha-stimulated vascular endothelial cells

7 January 2021

1 reference

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The effects of bosentan, aminoguanidine and L-canavanine on mesenteric blood flow, spleen and liver in endotoxaemic mice

7 January 2021

1 reference

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Endothelin 1 aggravates acute liver injury in perfused livers of rats after treatment with D-galactosamine

7 January 2021

1 reference

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Endothelin receptor subtype B mediates autoinduction of endothelin-1 in rat mesangial cells

7 January 2021

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Tissue expression of endothelin-1 mRNA in endotoxaemia.

7 January 2021

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Cardiopulmonary effects of endothelin-1 in man

7 January 2021

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Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1

7 January 2021

1 reference

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Role of endogenous endothelin in gastric mucosal injury induced by hemorrhagic shock in rats

7 January 2021

1 reference

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Hypoxia induces endothelin gene expression and secretion in cultured human endothelium

7 January 2021

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The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations

7 January 2021

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The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators

7 January 2021

1 reference

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Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum

7 January 2021

1 reference

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Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells

7 January 2021

1 reference

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Endothelin-1 in acute lung injury and the adult respiratory distress syndrome

7 January 2021

1 reference

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Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin has biological actions at pathophysiological concentrations

7 January 2021

1 reference

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Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle

7 January 2021

1 reference

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Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart

7 January 2021

1 reference

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Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles

7 January 2021

1 reference

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Heterogeneity of endothelin-B receptors in rabbit pulmonary resistance arteries.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Production of endothelin-1 in vascular endothelial cells is regulated by factors associated with vascular injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta

7 January 2021

1 reference

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Transcriptional regulation of the endothelin-1 gene by TNF-alpha

7 January 2021

1 reference

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Endothelin (ET)-1 induced mucosal damage in the rat small intestine: role of ET(A) receptors

7 January 2021

1 reference

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Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: role of endogenous endothelin-1

7 January 2021

1 reference

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Specific binding of endothelin on human bronchial smooth muscle cells in culture and secretion of endothelin-like material from bronchial epithelial cells

7 January 2021

1 reference

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Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin-3-induced microvascular incompetence and mitochondrial damage in rat myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum

7 January 2021

1 reference

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Role of endothelin 1 in hemorrhagic shock-induced gastric mucosal injury in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries

7 January 2021

1 reference

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Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats

7 January 2021

1 reference

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Pathologic role of endothelin-1 in septic shock

7 January 2021

1 reference

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Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist.

7 January 2021

1 reference

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Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium

7 January 2021

1 reference

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Endothelin A-receptor blockade worsens endotoxin-induced hepatic microcirculatory changes and necrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Role of endothelin in acute renal failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Differentiated effects on splanchnic homeostasis by selective and non-selective endothelin receptor antagonism in porcine endotoxaemia

7 January 2021

1 reference

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The C-terminal fragment of big endothelin-1 does not potentiate the vasoactive effects of endothelin-1

7 January 2021

1 reference

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Coexpression studies with endothelin receptor subtypes indicate the existence of intracellular cross-talk between ET(A) and ET(B) receptors

7 January 2021

1 reference

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Tissue specific distribution, clearance and vascular effects of endothelin in the pig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Increased plasma levels of endothelin-like immunoreactivity during endotoxin administration in the pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Expression of endothelin peptides and mRNA in the human heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin-1 induces endothelial barrier failure in the cat hindlimb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Inducible endothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Effect of selective blockade of endothelin ETB receptors on the liver dysfunction and injury caused by endotoxaemia in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Role of endogenous endothelin-1 in stress-induced gastric mucosal damage and acid secretion in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Effects of endothelin on hemodynamics, prostaglandins, blood coagulation and renal function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Thromboxane A2-receptor blockade and prostacyclin in porcine Escherichia coli shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin in the gastrointestinal tract. Presence of endothelinlike immunoreactivity, endothelin-1 messenger RNA, endothelin receptors, and pharmacological effect

7 January 2021

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Hepatic sinusoidal cells and sinusoidal circulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Plasma endothelin-1 in acute myocardial infarction with heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Myocardial cell injury in septic shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin(A)-receptor antagonism attenuates pulmonary hypertension in porcine endotoxin shock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Effects on haemodynamics by selective endothelin ET(B) receptor and combined endothelin ET(A)/ET(B) receptor antagonism during endotoxin shock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Porcine intrinsic pulmonary and systemic vascular tone is endothelin-dependent.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Differences in vascular effects and removal of endothelin-1 in human lung, brain, and skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

ET-3 is extracted by and induces potent vasoconstriction in human splanchnic and renal vasculatures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Inhibitory effects of diclofenac on the endotoxin shock response in relation to endothelin turnover in the pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Bosentan-improved cardiopulmonary vascular performance and increased plasma levels of endothelin-1 in porcine endotoxin shock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelins mediate intestinal hypoperfusion during bacteremia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Hepatoprotective effect of a nonselective endothelin receptor antagonist (TAK-044) in the transplanted liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

Potential roles for endothelins in systemic inflammatory response syndrome with a particular relationship to cytokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900675-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(00)00675-0

1 reference

30 July 2017

1 reference