(Q34094851)

31 July 2017

title

Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats (English)

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31 July 2017

2

Papp M

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31 July 2017

Gittos MW

1

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31 July 2017

language of work or name

English

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publication date

1 October 2001

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European Neuropsychopharmacology

31 July 2017

published in

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31 July 2017

volume

11

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31 July 2017

issue

5

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31 July 2017

page(s)

351-357

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AGN 2979 [3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4, 4-dimethylpiperidine-2,6-dione]. An inhibitor of the activation of tryptophan hydroxylase.

31 July 2017

cites work

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Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress

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[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.

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7 January 2021

Antidepressant effect of a tryptophan hydroxylase activation inhibitor, AGN 2979

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An evaluation of the anxiolytic SC 48,274 in generalized anxiety disorder (GAD)

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Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound

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p-chlorophenylalanine-induced serotonin depletion: reduction in exploratory locomotion but no obvious sensory-motor deficits.

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Injection of 5-HT into the nucleus accumbens reduces the effects of d-amphetamine on responding for conditioned reward.

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Effect of potassium channel modulators in mouse forced swimming test

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A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study.

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The anxiolytic SC 48274 (AGN 2979; BTG 1501) in generalized anxiety disorder

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Additive effects of glyburide and antidepressants in the forced swimming test: evidence for the involvement of potassium channel blockade

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Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia

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Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors

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Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline

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7 January 2021

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

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Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine

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7 January 2021

Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression

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7 January 2021

The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression

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The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice

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Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

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7 January 2021

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

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7 January 2021

Block of potassium currents in rat isolated sympathetic neurones by tricyclic antidepressants and structurally related compounds

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7 January 2021

Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery

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7 January 2021

10.1016/S0924-977X(01)00103-1

Identifiers

DOI

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31 July 2017

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