(Q34097954)

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Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines

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Europe PubMed Central

PubMed publication ID

31 July 2017

Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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Aggregatibacter actinomycetemcomitans

object named as

Aggregatibacter actinomycetemcomitans

1 reference

based on heuristic

inferred from title

4

object named as

Mensur Dlakić

0 references

Kathleen Boesze-Battaglia

5

object named as

Kathleen Boesze-Battaglia

0 references

author name string

Bruce J Shenker

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Lisa P Walker

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Ali Zekavat

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

publication date

1 May 2014

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Cellular Microbiology

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1391-1404

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

The keystone-pathogen hypothesis.

1 reference

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5 July 2018

Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis

1 reference

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5 July 2018

A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium

1 reference

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5 July 2018

PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

The biology of the cytolethal distending toxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1

1 reference

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5 July 2018

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

1 reference

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5 July 2018

Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase

1 reference

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5 July 2018

Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia

1 reference

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5 July 2018

Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro

1 reference

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5 July 2018

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Role of phosphoinositide 3-kinase in innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Opposite regulation of IL-1beta and secreted IL-1 receptor antagonist production by phosphatidylinositide-3 kinases in human monocytes activated by lipopolysaccharides or contact with T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Assembly and function of a bacterial genotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

1 reference

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5 July 2018

The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Expression of the cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

The cytolethal distending toxin family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

RTX toxins recognize a beta2 integrin on the surface of human target cells

1 reference

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5 July 2018

Effect of cytolethal distending toxin on F-actin assembly and cell division in Chinese hamster ovary cells.

1 reference

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5 July 2018

A diffusible cytotoxin of Haemophilus ducreyi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Examination of diarrheagenicity of cytolethal distending toxin: suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Prevalence of cytolethal distending toxin production in Campylobacter jejuni and relatedness of Campylobacter sp. cdtB gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Immune suppression induced by Actinobacillus actinomycetemcomitans: effects on immunoglobulin production by human B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

5 July 2018

Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

Distribution of the cytolethal distending toxin A gene (cdtA) among species of Shigella and Vibrio, and cloning and sequencing of the cdt gene from Shigella dysenteriae.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt): evidence that the holotoxin is composed of three subunits: CdtA, CdtB, and CdtC.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

The TSC-mTOR signaling pathway regulates the innate inflammatory response

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12299

21 January 2018

Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146646

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Serum cytokine levels in periodontitis patients in relation to the bacterial load

1 reference

https://pubmed.ncbi.nlm.nih.gov/24697951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cell cycle arrest in lymphocytes by Actinobacillus actinomycetemcomitans cytolethal distending toxin requires three subunits for maximum activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24697951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of Haemophilus ducreyi and purified cytolethal distending toxin with human monocyte-derived dendritic cells, macrophages and CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24697951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune suppression induced by Actinobacillus actinomycetemcomitans. I. Effects on human peripheral blood lymphocyte responses to mitogens and antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/24697951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Human T Cells That Coexpress CD4 and CD8 by an Immunomodulatory Protein Produced by Actinobacillus actinomycetemcomitans

1 reference

https://pubmed.ncbi.nlm.nih.gov/24697951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/CMI.12299

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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