(Q34103432)

31 July 2017

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title

Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites (English)

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31 July 2017

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Erlandsen H

1

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31 July 2017

Abola EE

series ordinal

2

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31 July 2017

Stevens RC

series ordinal

3

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31 July 2017

publication date

1 December 2000

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Current Opinion in Structural Biology

31 July 2017

published in

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31 July 2017

volume

10

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31 July 2017

issue

6

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31 July 2017

page(s)

719-730

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Class-directed structure determination: foundation for a protein structure initiative

31 July 2017

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Structural motif of phosphate-binding site common to various protein superfamilies: all-against-all structural comparison of protein-mononucleotide complexes

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NAD-binding domains of dehydrogenases

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Conserved supersecondary structural motif in NAD-dependent dehydrogenases

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Catecholamine biosynthesis and physiological regulation in neuroendocrine cells

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7 January 2021

Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria

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7 January 2021

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

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7 January 2021

Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases

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7 January 2021

Crystal structure of a plant catechol oxidase containing a dicopper center

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7 January 2021

The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity

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7 January 2021

Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms

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7 January 2021

Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site

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7 January 2021

Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution

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7 January 2021

Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase

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7 January 2021

Mutation to phenylalanine of tyrosine 371 in tyrosine hydroxylase increases the affinity for phenylalanine

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7 January 2021

Site-directed mutants of charged residues in the active site of tyrosine hydroxylase

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7 January 2021

Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation

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7 January 2021

The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters

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7 January 2021

Tetrahydrobiopterin biosynthesis, regeneration and functions

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7 January 2021

Crystal structure of catechol O-methyltransferase

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7 January 2021

The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants

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7 January 2021

The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold

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7 January 2021

The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography

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7 January 2021

One motif--many different reactions

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7 January 2021

Protein folds and functions

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7 January 2021

Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences

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7 January 2021

The structure of mammalian hexokinase-1

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7 January 2021

Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control

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Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation

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7 January 2021

The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin

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7 January 2021

The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition

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7 January 2021

Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator

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7 January 2021

Phosphofructokinase: structure and control

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7 January 2021

Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products

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7 January 2021

Structural basis of the allosteric behaviour of phosphofructokinase

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7 January 2021

Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications

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7 January 2021

Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)

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7 January 2021

The crystal structure of Escherichia coli class II fructose-1, 6-bisphosphate aldolase in complex with phosphoglycolohydroxamate reveals details of mechanism and specificity

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7 January 2021

Product binding and role of the C-terminal region in class I D-fructose 1,6-bisphosphate aldolase

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7 January 2021

Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95

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7 January 2021

Structure of yeast triosephosphate isomerase at 1.9-A resolution

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7 January 2021

Refined 1.83 Å structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 m-ammonium sulphate

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7 January 2021

The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes

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7 January 2021

Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway

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7 January 2021

Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase

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7 January 2021

Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes

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7 January 2021

Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation

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7 January 2021

Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability

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7 January 2021

Structure of the R65Q mutant of yeast 3-phosphoglycerate kinase complexed with Mg-AMP-PNP and 3-phospho-D-glycerate

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7 January 2021

Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis

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7 January 2021

Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A

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7 January 2021

Mechanism of enolase: the crystal structure of enolase-Mg2(+)-2-phosphoglycerate/phosphoenolpyruvate complex at 2.2-A resolution

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7 January 2021

Inhibition of enolase: the crystal structures of enolase-Ca2(+)- 2-phosphoglycerate and enolase-Zn2(+)-phosphoglycolate complexes at 2.2-A resolution

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7 January 2021

Catalytic metal ion binding in enolase: the crystal structure of an enolase-Mn2+-phosphonoacetohydroxamate complex at 2.4-A resolution

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7 January 2021

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

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7 January 2021

Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel

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7 January 2021

Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction

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7 January 2021

Visualization of dioxygen bound to copper during enzyme catalysis

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7 January 2021

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans

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7 January 2021

X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity

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7 January 2021

Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes

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7 January 2021

Structural basis of autoregulation of phenylalanine hydroxylase

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7 January 2021

10.1016/S0959-440X(00)00154-8

Identifiers

DOI

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31 July 2017

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