(Q34104378)

English

A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?

scientific article published in February 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

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Europe PubMed Central

A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? (English)

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

amyotrophic lateral sclerosis

0 references

Mark C. Bellingham

1

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

author name string

Mark C Bellingham

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

publication date

1 February 2011

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

CNS Neuroscience & Therapeutics

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

17

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

1

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

4-31

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

The pharmacology and mechanism of action of riluzole

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

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Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study

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21 January 2018

Riluzole in Huntington's disease: a 3-year, randomized controlled study

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21 January 2018

Riluzole in the treatment of mood and anxiety disorders

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21 January 2018

Riluzole in psychiatry: a systematic review of the literature

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21 January 2018

1 reference

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21 January 2018

Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis

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21 January 2018

Electrophysiology of the neuroprotective agent riluzole on striatal spiny neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effects of riluzole on rat cortical neurones: an in vitro electrophysiological study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

1 reference

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21 January 2018

Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole

1 reference

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21 January 2018

Intrinsic spontaneous activity and subthreshold oscillations in neurones of the rat dorsal column nuclei in culture.

1 reference

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21 January 2018

Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability

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21 January 2018

Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region

1 reference

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21 January 2018

Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones

1 reference

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21 January 2018

Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats

1 reference

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21 January 2018

Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.

1 reference

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21 January 2018

The whisking rhythm generator: a novel mammalian network for the generation of movement

1 reference

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21 January 2018

Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Persistent sodium current contributes to induced voltage oscillations in locomotor-related hb9 interneurons in the mouse spinal cord

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole-Sensitive Slowly Inactivating Sodium Current in Rat Suprachiasmatic Nucleus Neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

INaP underlies intrinsic spiking and rhythm generation in networks of cultured rat spinal cord neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole inhibits spontaneous Ca2+ signaling in neuroendocrine cells by activation of K+ channels and inhibition of Na+ channels.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Respiratory rhythm: an emergent network property?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Persistent sodium current in mammalian central neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Resurgence of sodium channel research

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region

1 reference

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21 January 2018

Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies.

1 reference

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21 January 2018

Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo

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21 January 2018

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure

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21 January 2018

A riluzole- and valproate-sensitive persistent sodium current contributes to the resting membrane potential and increases the excitability of sympathetic neurones

1 reference

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21 January 2018

Interaction of high concentrations of riluzole with recombinant skeletal muscle sodium channels and adult-type nicotinic receptor channels

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21 January 2018

Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells

1 reference

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21 January 2018

Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents.

1 reference

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21 January 2018

Respiratory rhythm generation during gasping depends on persistent sodium current.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Is the persistent sodium current a specific target of anti-absence drugs?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Molecular diversity of K+ channels

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Interaction of riluzole with the closed inactivated state of Kv4.3 channels.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Inhibition of the cloned delayed rectifier K+ channels, Kv1.5 and Kv3.1, by riluzole

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Channels underlying neuronal calcium-activated potassium currents

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Pharmacological modulation of SK3 channels.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation

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21 January 2018

Pharmacology of neuronal background potassium channels

1 reference

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21 January 2018

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.

1 reference

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21 January 2018

Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1

1 reference

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21 January 2018

Pharmacological characterization of a non-inactivating outward current observed in mouse cerebellar Purkinje neurones

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21 January 2018

Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Calcium channels coupled to glutamate release identified by omega-Aga-IVA.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells

1 reference

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21 January 2018

Effects of depolarizing stimuli on calcium homeostasis in cultured rat motoneurones

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Selective inhibition by riluzole of voltage-dependent sodium channels and catecholamine secretion in adrenal chromaffin cells

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21 January 2018

2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--II. Biochemical properties.

1 reference

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21 January 2018

Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effects of riluzole on electrically evoked neurotransmitter release

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole anesthesia: use-dependent block of presynaptic glutamate fibers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Control of presynaptic function by a persistent Na(+) current

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Interaction of the neuroprotective drug riluzole with GABA(A) and glycine receptor channels

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABA(A)-receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Direct effects of riluzole on 5-hydroxytryptamine (5-HT)3 receptor-activated ion currents in NCB-20 neuroblastoma cells

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21 January 2018

Role of motility in chronic diarrhoea.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole serum concentrations in patients with ALS: associations with side effects and symptoms.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Design, power, and interpretation of studies in the standard murine model of ALS

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Delayed riluzole treatment is able to rescue injured rat spinal motoneurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Liquid chromatographic assay for riluzole in mouse plasma and central nervous system tissues

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole, a glutamate release inhibitor, and motor behavior.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Mechanisms of Na+ and Ca2+ influx into respiratory neurons during hypoxia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Determinants of inspiratory activity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Audit of outcomes in motor neuron disease (MND) patients treated with riluzole.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Early symptom progression rate is related to ALS outcome: a prospective population-based study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole therapy for motor neurone disease: an early Australian experience (1996-2002).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

An analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzole

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole and amyotrophic lateral sclerosis survival: a population-based study in southern Italy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Long-term safety of riluzole in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

German open label trial of riluzole 50 mg b.i.d. in treatment of amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The Rilutek (riluzole) Global Early Access Programme: an open-label safety evaluation in the treatment of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole-induced neutropenia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Hypersensitivity pneumonitis possibly caused by riluzole therapy in ALS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole-induced acute pancreatitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Reversible granulocytopenia in association with riluzole therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Blood pressure elevations in riluzole-treated patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

An association study of riluzole serum concentration and survival and disease progression in patients with ALS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Pharmacologic reversal of cortical hyperexcitability in patients with ALS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

The effect of riluzole in amyotrophic lateral sclerosis: a study with cortical stimulation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Increased nodal persistent Na+ currents in human neuropathy and motor neuron disease estimated by latent addition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Cell death during development of the nervous system

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Motoneurons crave glial cell line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Early treatment with noninvasive positive pressure ventilation prolongs survival in Amyotrophic Lateral Sclerosis patients with nocturnal respiratory insufficiency.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Sleep-disordered breathing in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole blocks dopamine release evoked by N-methyl-D-aspartate, kainate, and veratridine in the rat striatum.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

Different types of calcium channels mediate central synaptic transmission

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2009.00116.X

21 January 2018

A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention by insulin-like growth factor-I and riluzole in motor neuron death after neonatal axotomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of riluzole-induced stimulation of large-conductance calcium-activated potassium channels in rat pituitary GH3 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole does not have an acute effect on motor thresholds and the intracortical excitability in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective depression of low-release probability excitatory synapses by sodium channel blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methemoglobinemia due to riluzole

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole inhibits the persistent sodium current in mammalian CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole prolongs survival and delays muscle strength deterioration in mice with progressive motor neuronopathy (pmn)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective agent riluzole dramatically slows inactivation of Kv1.4 potassium channels by a voltage-dependent oxidative mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological properties of benzazoles. I. Relationship between structure and paralyzing action

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An important functional role of persistent Na+ current in carotid body hypoxia transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent inward currents in rat ventral horn neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ventral medullary respiratory network of the mature mouse studied in a working heart-brainstem preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate antagonist riluzole suppresses intracortical facilitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single- and multiple-dose pharmacokinetics of riluzole in white subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole has no acute effect on motor unit parameters in ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20236142

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1755-5949.2009.00116.X

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493865

ResearchGate publication ID

0 references

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